Evidence map›Paper›PMID 30914425›Full record

ArticleG3 (Bethesda, Md.)2019

Identification of a Rat Mammary Tumor Risk Locus That Is Syntenic with the Commonly Amplified 8q12.1 and 8q22.1 Regions in Human Breast Cancer Patients.

Cody Plasterer, Shirng-Wern Tsaih, Angela Lemke, Rebecca Schilling, Melinda Dwinell, Andrea Rau, Paul Auer, Hallgeir Rui, Michael J Flister

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Pharmacological inhibition of MDA-9/Syntenin blocks breast cancer metastasis through suppression of IL-1β.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  4. Article
  5. Article
  6. Identification of Hub Genes Using Co-Expression Network Analysis in Breast Cancer as a Tool to Predict Different Stages.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Cody PlastererGenomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI.
Shirng-Wern TsaihGenomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI.
Angela LemkeGenomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI.
Rebecca SchillingGenomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI.
Melinda DwinellGenomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI.
Andrea RauJoseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee.
Paul AuerJoseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee.
Hallgeir RuiDepartment of Pathology, Medical College of Wisconsin, Milwaukee, WI.
Michael J FlisterGenomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI mflister@mcw.edu.ORCID 0000-0001-8030-7739
Medical College of Wisconsin · USUniversité Paris-Saclay · FRUniversity of Wisconsin–Milwaukee · US

Funding

INTEGRATED PHYSIOLOGY TRAINING--MOLECULE TO ORGANISMT32HL007852 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Matthew Robert Hodges · 1996 to 2026
$6.5M
Leveraging genetic mapping for personalized targeting of breast cancer microenvironmentR01CA193343 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amit Joshi · 2015 to 2026
$3.5M
Prolactin pathways and metastatic progression of ER-positive breast cancerR01CA188575 · NCI · THOMAS JEFFERSON UNIVERSITY · PI RUI, HALLGEIR · 2015 to 2019
$1.8M
NCI NIH HHS R01 CA188575NCI NIH HHS R01 CA193343NHLBI NIH HHS T32 HL007852
6 · The paper itself

Abstract

Breast cancer risk is 31% heritable, yet the majority of the underlying risk factors remain poorly defined. Here, we used F2-linkage analysis in a rat mammary tumor model to identify a novel 11.2 Mb modifier locus of tumor incidence and burden on rat chromosome 5 (chr5: 15.4 - 26.6 Mb). Genomic and RNA sequencing analysis identified four differentially expressed candidates:

Indexed as

Chromosomes, Human, Pair 8Gene AmplificationGenetic Predisposition to DiseaseQuantitative Trait LociAnimalsBreast NeoplasmsChromosome MappingFemaleGene Expression ProfilingGenome, HumanGenomicsHigh-Throughput Nucleotide SequencingHumansMammary Neoplasms, AnimalRatsTumor Burdenbreast cancerincidenceoutcomeriskTCGA

Identifiers

PMID30914425
PMCPMC6505137
OpenAlexW2923728663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.