Evidence map›Paper›PMID 30914419›Full record

ArticleThe Journal of cell biology2019

Homeostatic scaling of active zone scaffolds maintains global synaptic strength.

Pragya Goel, Dominique Dufour Bergeron, Mathias A Böhme, Luke Nunnelly, Martin Lehmann, Christopher Buser, Alexander M Walter, Stephan J Sigrist, Dion Dickman

Abstract read
In one paragraph

Article in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Nonionic signaling rapidly remodels postsynaptic DLG to induce retrograde homeostatic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Active Zone Maturation Controls Presynaptic Output and Release Mode and Is Regulated by Neuronal Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Presynaptic neurons self-tune by inversely coupling neurotransmitter release with the abundance of CaV2 voltage-gated CaProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. A non-conducting role of the CabioRxiv : the preprint server for biology · 2024
    Article
  18. Article
  19. Muscle-fiber specific genetic manipulation ofFrontiers in physiology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Pragya GoelDepartment of Neurobiology, University of Southern California, Los Angeles, CA.
Dominique Dufour BergeronInstitute for Biology, Freie Universität Berlin, Berlin, Germany.
Mathias A BöhmeNeurocure Cluster of Excellence, Charité Universitätsmedizin, Berlin, Germany.
Luke NunnellyDepartment of Neurobiology, University of Southern California, Los Angeles, CA.ORCID 0000-0002-9639-6411
Martin LehmannLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
Christopher BuserOak Crest Institute of Science, Monrovia, CA.ORCID 0000-0002-4379-3878
Alexander M WalterNeurocure Cluster of Excellence, Charité Universitätsmedizin, Berlin, Germany.ORCID 0000-0001-5646-4750
Stephan J SigristInstitute for Biology, Freie Universität Berlin, Berlin, Germany.ORCID 0000-0002-1698-5815
Dion DickmanDepartment of Neurobiology, University of Southern California, Los Angeles, CA dickman@usc.edu.ORCID 0000-0003-1884-284X

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Molecular Mechanisms Governing the Homeostatic Control of Synaptic StrengthR01NS091546 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2015 to 2024
$4.3M
Synaptic Control of Glutamate HomeostasisR01NS111414 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2019 to 2023
$1.8M
NIH HHS P40 OD018537NINDS NIH HHS R01 NS091546NINDS NIH HHS R01 NS111414
6 · The paper itself

Abstract

Synaptic terminals grow and retract throughout life, yet synaptic strength is maintained within stable physiological ranges. To study this process, we investigated

Indexed as

Axonal TransportHomeostasisAnimalsDrosophila melanogasterDrosophila ProteinsMutationNeuromuscular Junctionrab3 GTP-Binding ProteinsSynapsesSynaptic TransmissionDrosophila Proteinsrab3 GTP-Binding ProteinsRab3 protein, Drosophila

Identifiers

PMID30914419
PMCPMC6504899

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.