ArticleCancer research and treatment2019
Clinical Significance of Pleural Attachment and Indentation of Subsolid Nodule Lung Cancer.
Article in Cancer research and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 55 citations in OpenAlex.
- Nomogram based on clinical characteristics and radiological features for the preoperative prediction of spread through air spaces in patients with clinical stage IA non-small cell lung cancer: a multicenter study.Diagnostic and interventional radiology (Ankara, Turkey) · 2023Trial
- Development and validation of a deep learning signature for predicting lymph node metastasis in lung adenocarcinoma: comparison with radiomics signature and clinical-semantic model.European radiology · 2023Trial
- Machine learning-based preoperative prediction of spread through air spaces in clinical stage IA non-small cell lung cancer: a single-center study integrating clinical and CT imaging characteristics.Journal of thoracic disease · 2026Article
- Density homogeneity as a crucial CT indicator for differentiating malignant and benign subcentimeter solid pulmonary nodules: A retrospective multi-center study.Insights into imaging · 2026Article
- CT predictors of visceral pleural invasion in subsolid nodular pulmonary adenocarcinoma: differences between direct and indirect tumor-pleura contact.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Observational
- A radiomics nomogram integrated with radiological features for preoperative prediction of lung nodule invasiveness: comparison with Lung-RADS.Translational lung cancer research · 2026Article
- Predicting visceral pleural invasion in invasive adenocarcinoma with a maximum diameter ≤ 3 cm based onEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Dual-layer spectral detector CT electron density imaging: impressive technology for imaging characteristics of ground-glass nodules.Quantitative imaging in medicine and surgery · 2025Article
- Prediction of visceral pleural invasion of clinical stage IA lung adenocarcinoma based on computed tomography features.Translational cancer research · 2025Article
- Significance of the Lesion-Pleura Relationship in Differentiating Peripheral Inflammatory Lesions and Lung Cancers.Journal of inflammation research · 2025Article
- Prognostic significance of visceral pleural changes in stage IA lung adenocarcinoma: a retrospective study.Frontiers in oncology · 2025Article
- Development and validation of a predictive model for lymph node metastases in peripheral non-small cell lung cancer with a tumor diameter ≤ 2.0 cm and a consolidation-to-tumor ratio > 0.5.Frontiers in oncology · 2025Article
- A deep learning approach for predicting visceral pleural invasion in cT1 lung adenocarcinoma.Journal of thoracic disease · 2024Article
- Intratumoral and peritumoral radiomics combined with computed tomography features for predicting the invasiveness of lung adenocarcinoma presenting as a subpleural ground-glass nodule with a consolidation-to-tumor ratio ≤50.Journal of thoracic disease · 2024Article
- Predictive value of spectral dual-detector computed tomography forQuantitative imaging in medicine and surgery · 2024Article
- Predicting bone metastasis-free survival in non-small cell lung cancer from preoperative CT via deep learning.NPJ precision oncology · 2024Article
- Nomogram using intratumoral and peritumoral radiomics for the preoperative prediction of visceral pleural invasion in clinical stage IA lung adenocarcinoma.Journal of cardiothoracic surgery · 2024Article
- CT-Based Intratumoral and Peritumoral Radiomics Nomograms for the Preoperative Prediction of Spread Through Air Spaces in Clinical Stage IA Non-small Cell Lung Cancer.Journal of imaging informatics in medicine · 2024Article
- Prognostic Analysis of Stage I Non-Small Cell Lung Cancer Abutting Adjacent Structures on Preoperative Computed Tomography.Journal of chest surgery · 2024Article
- Research progress in predicting visceral pleural invasion of lung cancer: a narrative review.Translational cancer research · 2024Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
purposeLung cancers presenting as subsolid nodule commonly have peripheral location, making the cancer-pleura relationship noteworthy. We aimed to evaluate the effect of pleural attachment and/or indentation on visceral pleural invasion (VPI) and recurrence-free survival. MATERIALS AND
methodsPatients who underwent curative resection of lung cancer as subsolid nodules from April 2007 to January 2016 were retrospectively evaluated. They were divided into four groups according to their relationship with the pleura. Clinical, radiographical, and pathological findings were analyzed.
resultsAmong 404 patients with malignant subsolid nodule, 120 (29.7%) had neither pleural attachment nor indentation, 26 (6.4%) had attachment only, 117 (29.0%) had indentation only, and 141 (34.9%) had both. VPI was observed in nodules of 36 patients (8.9%), but absent in nonsolid nodules and in those without pleural attachment and/or indentation. Compared to subsolid nodules with concurrent pleural attachment and indentation, those with attachment only (odds ratio, 0.12; 95% confidence interval [CI], 0.02 to 0.98) and indentation only (odds ratio, 0.10; 95% CI, 0.03 to 0.31) revealed lower odds of VPI. On subgroup analysis, the size of the solid portion was associated with VPI among those with pleural attachment and indentation (p=0.021). Such high-risk features for VPI were associated with earlier lung cancer recurrence (adjusted hazard ratio, 3.31; 95% CI, 1.58 to 6.91).
conclusionConcurrent pleural attachment and indentation are risk factors for VPI, and the odds increase with larger solid portion in subsolid nodules. Considering the risk of recurrence, early surgical resection could be encouraged in these patients.
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