Evidence map›Paper›PMID 30913381›Full record

Trial reportCancer cytopathology2019

Comparison of nylon-flocked swab and Dacron swab cytology for anal HSIL detection in transgender women and gay, bisexual, and other men who have sex with men.

Dorothy J Wiley, Hilary K Hsu, Martha A Ganser, Jenny Brook, David A Elashoff, Matthew G Moran, Stephen A Young, Nancy E Joste, Ronald Mitsuyasu, Teresa M Darragh and 7 more

Erratum issuedOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer cytopathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. German-Austrian guideline on screening for anal dysplasia and anal carcinoma in people living with HIV.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025
    Guideline
  2. Pooled it
  3. Trial
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Dorothy J WileySchool of Nursing, University of California Los Angeles, Los Angeles, California.ORCID 0000-0002-9416-473X
Hilary K HsuSchool of Nursing, University of California Los Angeles, Los Angeles, California.ORCID 0000-0003-4608-4935
Martha A GanserSchool of Nursing, University of California Los Angeles, Los Angeles, California.
Jenny BrookDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
David A ElashoffDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Matthew G MoranSchool of Nursing, University of California Los Angeles, Los Angeles, California.
Stephen A YoungTricore Reference Laboratories, University of New Mexico, Albuquerque, New Mexico.
Nancy E JosteTricore Reference Laboratories, University of New Mexico, Albuquerque, New Mexico.
Ronald MitsuyasuDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Teresa M DarraghDepartment of Pathology, University of California San Francisco, San Francisco, California.
David H MorrisDesert AIDS Project, Palm Springs, California.
Otoniel M Martínez-MazaDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Roger DetelsJonathan and Karen Fielding School of Public Health, University of California Los Angeles, Los Angeles, California.
Jian Yu RaoDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Robert K BolanLos Angeles LGBT Center, Los Angeles, California.
Eric T ShigenoSchool of Nursing, University of California Los Angeles, Los Angeles, California.
Ernesto RodriguezSchool of Nursing, University of California Los Angeles, Los Angeles, California.
University of California, Los Angeles · USUniversity of New Mexico · USDesert AIDS Project · USLos Angeles LGBT Center · USUniversity of California, San Francisco · US

Funding

NATURAL HISTORY OF AIDS IN HOMOSEXUAL MENU01AI035040 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DETELS, ROGER, MARTINEZ-MAZA, OTONIEL · 1993 to 2018
$75.2M
University of Pittsburgh Multicenter AIDS Cohort Study (MACS)U01AI035041 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARTINSON, JEREMY JAMES, RINALDO, CHARLES R · 1993 to 2018
$71.4M
MULTICENTER AIDS COHORT STUDYU01AI035039 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLINSKY, STEVEN M · 1993 to 2018
$66.4M
Multicenter Aids Cohort Study- Part B (Baltimore Site)U01AI035042 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T, MARGOLICK, JOSEPH B. · 1993 to 2018
$61.5M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAPHAEL J LANDOVITZ · 1997 to 2026
$53.5M
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7M
Study of Hearing and Balance in Middle Aged and Aging Men and Women in the MACS-WIHS Combined Cohort StudyU01HL146333 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Roger Detels, Matthew James Mimiaga · 2019 to 2026
$32.2M
Center for the Analysis & Management of the Multicenter AIDS Cohort StudyUM1AI035043 · NIAID · JOHNS HOPKINS UNIVERSITY · PI D'SOUZA, GYPSYAMBER, JACOBSON, LISA P · 2012 to 2018
$20.7M
Improving screening tools to better predict high-grade anal dysplasia for MSMR01CA169508 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WILEY, DOROTHY J. · 2013 to 2017
$3.1M
NCATS NIH HHS UL1 TR001079NCI NIH HHS R01 CA169508NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146333NIAID NIH HHS U01 AI035039NIAID NIH HHS U01 AI035040NIAID NIH HHS U01 AI035041NIAID NIH HHS U01 AI035042NIAID NIH HHS UM1 AI035043NIMH NIH HHS P30 MH058107
6 · The paper itself

Abstract

backgroundAn anal histological high-grade squamous intraepithelial lesion (hHSIL) is an anal cancer precursor. Experts recommend Dacron swab anal cytology as a primary screen for anal hHSILs, especially among human immunodeficiency virus-infected and -uninfected men who have sex with men (MSM). Studies have shown that Dacron cytology inaccurately predicts anal hHSILs and results in unnecessary diagnostic procedures. Nylon-flocked (NF) swabs have been shown to trap pathogens and cells well. Thus, this study compared test characteristics of anal cytology using NF and Dacron swab collection protocols to predict anal hHSILs.

methodsA single-visit, randomized clinical trial compared NF and Dacron swab anal cytology specimens to predict high-resolution anoscopy and biopsy-diagnosed anal hHSILs. Data for 326 gay men, bisexual men, other MSM, and male-to-female transgender women contributed descriptive and tabular statistics with which unadjusted and fully adjusted logistic regression models were constructed. The models estimated the odds of hHSILs, test accuracy (area under the curve [AUC]) and sensitivity, and specificity as well as the positive and negative predictive values of abnormal NF and Dacron cytology for predicting hHSILs.

resultsIn the fully adjusted model, the sensitivities for NF and Dacron cytology were nearly equal (48% vs 47%), but the specificity was higher with NF cytology (76% vs 69%). Comparisons of the areas under receiver operating characteristic curves showed that NF cytology alone predicted hHSILs better than the covariate model (AUC, 0.69 vs 0.63; P = .02), but NF and Dacron cytology comparisons showed no statistically significant differences (AUC, 0.69 vs 0.67; P = .3).

conclusionsNF cytology and Dacron cytology provide modest sensitivity, but NF cytology has higher specificity and accuracy, and this is important for lowering the costs of population-based screening.

Indexed as

Anus NeoplasmsCytodiagnosisFemaleFollow-Up StudiesHIV-1HIV InfectionsHomosexuality, MaleHumansMaleMiddle AgedNylonsPolyethylene TerephthalatesPrognosisSexual and Gender MinoritiesSpecimen HandlingSquamous Intraepithelial LesionsNylonsPolyethylene Terephthalatesanal cancer screeninganal cytologyanal high-grade dysplasiaanal high-grade squamous intraepithelial lesion (HSIL) screeningcancer screening

Identifiers

PMID30913381
PMCPMC7108036
OpenAlexW2925052470

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.