Evidence map›Paper›PMID 30913377›Full record

ArticleThe Kaohsiung journal of medical sciences2019

Resveratrol alleviate the injury of mice liver induced by cadmium sulfide nanoparticles.

Chun-Yan Meng, Ya-Feng Han, Ying-Li Liu, Hong-Xia Gao, Yi-Yi Ren, Qing-Zeng Qian, Qian Wang, Qing-Zhao Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Kaohsiung journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chun-Yan MengLaboratory of Coal Mine Health and Safety, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, PR China.ORCID https://orcid.org/0000-0002-9851-1030
Ya-Feng HanThe section of Infectious Disease Control, Tianjin Hebei District Center for Disease Control and Prevention, Tianjin, PR China.
Ying-Li LiuLaboratory of Coal Mine Health and Safety, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, PR China.
Hong-Xia GaoLaboratory of Coal Mine Health and Safety, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, PR China.
Yi-Yi RenLaboratory of Coal Mine Health and Safety, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, PR China.
Qing-Zeng QianLaboratory of Coal Mine Health and Safety, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, PR China.
Qian WangLaboratory of Coal Mine Health and Safety, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, PR China.
Qing-Zhao LiLaboratory of Coal Mine Health and Safety, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, PR China.
North China University of Science and Technology · CNTianjin Centers for Disease Control and Prevention · CN

Funding

Hebei province Commission of Population and Family Planning 20180749
6 · The paper itself

Abstract

Cadmium sulfide nanoparticle (Nano-CdS) is a kind of important semiconductor material with special photochemistry property. With the Nano-CdS being widely used, the security problems it caused have been catching more and more attention. This study aims to explore the possible mechanism of liver injury induced by Nano-CdS and whether resveratrol can reduce the damage. In this study, male BALB/C mice were treated with Nano-CdS with a diameter of 20 to 30 nm and a length of 80 to 100 nm. It turned out that the mice liver inflammatory cells infiltrated, the liver tissue and the ultrastructure changed; The activities of T-AOC and GSH were suppressed (n = 6, P < 0.05) and the content of lipid peroxide (MDA) increased (n = 6, P < 0.05). Besides, Nano-CdS decreased the mRNA expression level of Sirt1 and FoxO1 genes in liver tissue (n = 3, P < 0.05). All the changes in the index were reversed by resveratrol. The mRNA expression level of FoxO3a showed no significant difference between the control group and the Nano-CdS group. But under the protection of resveratrol, the mRNA expression level of FoxO3a was higher than that in the control and Nano-CdS groups (n = 3, P < 0.05). Results suggest that Nano-CdS can cause oxidative damages to liver tissues in mice, in which process that the Sirt1 and FoxO1 genes may participate, and the damage can be reversed by resveratrol which may be a potential cure for oxidative damage to nanomaterials.

Indexed as

AnimalsAntioxidantsCadmium CompoundsChemical and Drug Induced Liver InjuryForkhead Box Protein O1Forkhead Box Protein O3Gene ExpressionGerm-Free LifeGlutathioneLiverMaleMalondialdehydeMiceMice, Inbred BALB CNanoparticlesOxidative StressAntioxidantsCadmium Compoundscadmium sulfideForkhead Box Protein O1Forkhead Box Protein O3Foxo1 protein, mouseFoxO3 protein, mouseGlutathioneMalondialdehydeResveratrolRNA, MessengerSirt1 protein, mouseSirtuin 1Sulfidescadmium sulfide nanoparticlesFoxOoxidative damageresveratrolSirt1

Identifiers

PMID30913377
PMCPMC11900743
OpenAlexW2925034141

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.