Evidence map›Paper›PMID 30913258›Full record

Trial reportPloS one2019

Autoantibodies are present before the clinical diagnosis of systemic sclerosis.

Peter D Burbelo, Sarah M Gordon, Meryl Waldman, Jess D Edison, Dustin J Little, Rodger S Stitt, Wayne T Bailey, James B Hughes, Stephen W Olson

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
  2. Article
  3. Predictive Autoantibodies Before the Diagnosis of Type I Diabetes in Adults.medRxiv : the preprint server for health sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Peter D BurbeloDental Clinical Research Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, United States of America.ORCID 0000-0003-1717-048X
Sarah M GordonNephrology Department, Walter Reed National Military Medical Center, Bethesda, MD, United States of America.
Meryl WaldmanKidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, and, National Institutes of Health, Bethesda, MD, United States of America.
Jess D EdisonRheumatology Department, Walter Reed National Military Medical Center, Bethesda, MD, United States of America.
Dustin J LittleNephrology Department, Walter Reed National Military Medical Center, Bethesda, MD, United States of America.
Rodger S StittRheumatology Department, Walter Reed National Military Medical Center, Bethesda, MD, United States of America.
Wayne T BaileyRheumatology Department, Walter Reed National Military Medical Center, Bethesda, MD, United States of America.
James B HughesUniformed Services University of the Health Sciences, Bethesda, MD, United States of America.ORCID 0000-0002-9290-1505
Stephen W OlsonNephrology Department, Walter Reed National Military Medical Center, Bethesda, MD, United States of America.
Walter Reed National Military Medical Center · USNational Institutes of Health · USUniformed Services University of the Health Sciences · US

Funding

NIDCR DIR Scientific Cores (Combined Technical Research Core)ZICDE000729 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI ABSHARI, MEHRNOOSH · 2009 to 2025
$31.7M
Intramural NIH HHS ZIC DE000729NIDCR NIH HHS ZIC DE000729
6 · The paper itself

Abstract

Systemic sclerosis (SSc) is a heterogeneous autoimmune disorder associated with vascular dysfunction and fibrotic changes in the skin, vasculature and internal organs. Although serologic abnormalities are an important diagnostic tool for SSc, little is known about whether autoantibodies precede clinical diagnosis. Here we investigated the presence of autoantibodies before SSc diagnosis and assessed whether certain autoantibodies might associate with the future onset of scleroderma renal crisis (SRC), a potentially fatal complication of the disease. Using the Department of Defense Serum Repository, autoantibodies were analyzed from archived, prospectively collected, longitudinal serum samples from sixteen individuals with SRC (SSc/SRC) and thirty cases of SSc without SRC (SSc/no SRC), matched for age, sex, and race. Seventy five percent (12/16) of the SSc/SRC and 40% (12/30) of the SSc/no SRC were seropositive for at least one autoantibody prior to clinical diagnosis (up to 27.1 years earlier, mean = -7.4 years). Although both disease groups demonstrated a heterogeneous immunoreactivity profile against the autoantigen panel, the SSc/SRC subjects showed two enriched clusters with one featuring elevated levels of autoantibodies against Ro52 and/or Ro60 and another with high levels of immunoreactivity against the RNA polymerase complex. Consistent with larger spectrum of immunoreactivity and the elevated levels of autoantibodies in SSc/SRC, the total response against the autoantigen panel from the last time point of the seropositive subjects revealed that the SSc/SRC cohort harbored higher antibody levels (p = 0.02) compared to SSc/no SRC. Overall, our findings demonstrate that relevant seropositive autoantibodies often precede the clinical diagnosis of SSc/no SRC and SSc/SRC.

Indexed as

AutoantibodiesScleroderma, SystemicAdultFemaleHumansMaleMiddle AgedRibonucleoproteinsSS-A AntigenAutoantibodiesRibonucleoproteinsSS-A Antigen

Identifiers

PMID30913258
PMCPMC6435159
OpenAlexW2924576972

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.