ArticleThe British journal of radiology2019
Multiparametric MRI-guided dose boost to dominant intraprostatic lesions in CT-based High-dose-rate prostate brachytherapy.
Article in The British journal of radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Imaging Biomarkers in Radiotherapy.Cancers · 2026Review
- A review of artificial intelligence in brachytherapy.Journal of applied clinical medical physics · 2025Review
- A review of whole gland prostate brachytherapy with focal dose escalation to intra-prostatic lesions: Clinical efficacy and technical aspects.Physics and imaging in radiation oncology · 2024Review
- Article
- Breathing-induced Errors in Quantification and Description of Dominant Intra-Prostatic Lesions (Dils) in PET Images: A Simulation Study by Means of The 4D NCAT Phantom.Journal of biomedical physics & engineering · 2022Article
- Dose differentiated high-dose-rate prostate brachytherapy: a feasibility assessment of MRI-guided dose escalation to dominant intra-prostatic lesions.Journal of contemporary brachytherapy · 2022Article
- MRI-based prostate and dominant lesion segmentation using cascaded scoring convolutional neural network.Medical physics · 2022Article
- Evaluation of Dose-Painting in the Dominant Intraprostatic Lesions by Radiobiological Parameters usingJournal of biomedical physics & engineering · 2022Article
- Intensity Modulated High Dose Rate (HDR) Brachytherapy Using Patient Specific 3D Metal Printed Applicators: Proof of Concept.Frontiers in oncology · 2022Article
- Prostate and dominant intraprostatic lesion segmentation on PET/CT using cascaded regional-net.Physics in medicine and biology · 2021Article
- Catheter position prediction using deep-learning-based multi-atlas registration for high-dose rate prostate brachytherapy.Medical physics · 2021Article
- Prostate specific membrane antigen positron emission tomography for lesion-directed high-dose-rate brachytherapy dose escalation.Physics and imaging in radiation oncology · 2021Article
- Multimodal MRI synthesis using unified generative adversarial networks.Medical physics · 2020Article
- Intensity non-uniformity correction in MR imaging using residual cycle generative adversarial network.Physics in medicine and biology · 2020Article
- Automatic multi-needle localization in ultrasound images using large margin mask RCNN for ultrasound-guided prostate brachytherapy.Physics in medicine and biology · 2020Article
- Multi-needle Localization with Attention U-Net in US-guided HDR Prostate Brachytherapy.Medical physics · 2020Article
- Impact of suboptimal dosimetric coverage of pretherapeutic 18F-FDG PET/CT hotspots on outcome in patients with locally advanced cervical cancer treated with chemoradiotherapy followed by brachytherapy.Clinical and translational radiation oncology · 2020Article
- A planning study of focal dose escalations to multiparametric MRI-defined dominant intraprostatic lesions in prostate proton radiation therapy.The British journal of radiology · 2020Article
- CT prostate segmentation based on synthetic MRI-aided deep attention fully convolution network.Medical physics · 2020Article
- Dosimetric Uncertainties in Dominant Intraprostatic Lesion Simultaneous Boost Using Intensity Modulated Proton Therapy.Advances in radiation oncologyArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe purpose of this study is to investigate the dosimetric feasibility of delivering focal dose to multiparametric (mp) MRI-defined DILs in CT-based high-dose-rate (HDR) prostate brachytherapy with MR/CT registration and estimate its clinical benefit.
methodsWe retrospectively investigated a total of 17 patients with mp-MRI and CT images acquired pre-treatment and treated by HDR prostate brachytherapy. 21 dominant intraprostatic lesions (DILs) were contoured on mp-MRI and propagated to CT images using a deformable image registration method. A boost plan was created for each patient and optimized on the original needle pattern. In addition, separate plans were generated using a virtually implanted needle around the DIL to mimic mp-MRI guided needle placement. DIL dose coverage and organ-at-rick (OAR) sparing were compared with original plan results. Tumor control probability (TCP) was estimated to further evaluate the clinical impact on the boost plans.
resultsOverall, optimized boost plans significantly escalated dose to DILs while meeting OAR constraints. The addition of mp-MRI guided virtual needles facilitate increased coverage of DIL volumes, achieving a V150 > 90% in 85 % of DILs compared with 57 % of boost plan without an additional needle. Compared with original plan, TCP models estimated improvement in DIL control by 28 % for patients with external-beam treatment and by 8 % for monotherapy patients.
conclusionWith MR/CT registration, the proposed mp-MRI guided DIL boost in CT-based HDR brachytherapy is feasible without violating OAR constraints, and indicates significant clinical benefit in improving TCP of DIL. It may represent a strategy to personalize treatment delivery and improve tumor control. ADVANCES IN KNOWLEDGE: This study investigated the feasibility of mp-MRI guided DIL boost in HDR prostate brachytherapy with CT-based treatment planning, and estimated its clinical impact by TCP and NTCP estimation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.