Evidence map›Paper›PMID 30912718›Full record

ArticleRadiology2019

Rapid Short-pulse Ultrasound Delivers Drugs Uniformly across the Murine Blood-Brain Barrier with Negligible Disruption.

Sophie V Morse, Antonios N Pouliopoulos, Tiffany G Chan, Matthew J Copping, Julien Lin, Nicholas J Long, James J Choi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Tetrazine-Inorganic chemistry frontiers · 2026
    Article
  8. Article
  9. Article
  10. Precise antibody delivery to the brain via nanobubble-actuated focused ultrasound alleviates depression.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Targeting diffuse midline gliomas: The promise of focused ultrasound-mediated blood-brain barrier opening.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sophie V MorseFrom the Departments of Bioengineering (S.V.M., A.N.P., M.J.C., J.L., J.J.C.) and Chemistry (T.G.C., N.J.L.), Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom.ORCID 0000-0001-5184-0200
Antonios N PouliopoulosFrom the Departments of Bioengineering (S.V.M., A.N.P., M.J.C., J.L., J.J.C.) and Chemistry (T.G.C., N.J.L.), Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom.ORCID 0000-0002-8891-1495
Tiffany G ChanFrom the Departments of Bioengineering (S.V.M., A.N.P., M.J.C., J.L., J.J.C.) and Chemistry (T.G.C., N.J.L.), Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom.
Matthew J CoppingFrom the Departments of Bioengineering (S.V.M., A.N.P., M.J.C., J.L., J.J.C.) and Chemistry (T.G.C., N.J.L.), Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom.
Julien LinFrom the Departments of Bioengineering (S.V.M., A.N.P., M.J.C., J.L., J.J.C.) and Chemistry (T.G.C., N.J.L.), Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom.
Nicholas J LongFrom the Departments of Bioengineering (S.V.M., A.N.P., M.J.C., J.L., J.J.C.) and Chemistry (T.G.C., N.J.L.), Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom.
James J ChoiFrom the Departments of Bioengineering (S.V.M., A.N.P., M.J.C., J.L., J.J.C.) and Chemistry (T.G.C., N.J.L.), Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom.
Imperial College London · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L015129/1Wellcome TrustWellcome Trust 104931/Z/14/Z
6 · The paper itself

Abstract

Background Previous work has demonstrated that drugs can be delivered across the blood-brain barrier by exposing circulating microbubbles to a sequence of long ultrasound pulses. Although this sequence has successfully delivered drugs to the brain, concerns remain regarding potentially harmful effects from disrupting the brain vasculature. Purpose To determine whether a low-energy, rapid, short-pulse ultrasound sequence can efficiently and safely deliver drugs to the murine brain. Materials and Methods Twenty-eight female wild-type mice underwent focused ultrasound treatment after injections of microbubbles and a labeled model drug, while three control mice were not treated (May-November 2017). The left hippocampus of 14 mice was exposed to low-energy short pulses (1 MHz; five cycles; peak negative pressure, 0.35 MPa) of ultrasound emitted at a rapid rate (1.25 kHz) in bursts (0.5 Hz), and another 14 mice were exposed to standard long pulses (10 msec, 0.5 Hz) containing 150 times more acoustic energy. Mice were humanely killed at 0 (

Indexed as

AnimalsBlood-Brain BarrierDrug Delivery SystemsFemaleFluorescent DyesHippocampusMiceMice, Inbred C57BLMicrobubblesSonicationTissue DistributionFluorescent Dyes

Identifiers

PMID30912718
PMCPMC6493324
OpenAlexW2923705519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.