ArticleThe journal of physical chemistry. B2019
Partition of Positively and Negatively Charged Tryptophan Ions in Membranes with Inverted Phospholipid Heads: Simulations and Experiments.
Article in The journal of physical chemistry. B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Design of Peptides for Membrane Insertion: The Critical Role of Charge Separation.The journal of physical chemistry. B · 2022Article
- Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Defect-Assisted Permeation Through a Phospholipid Membrane: Experimental and Computational Study of the Peptide WKW.The journal of physical chemistry. B · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A joint experimental and computational study illustrates that the partitioning of positively and negatively charged tryptophan in a phospholipid bilayer is significantly altered by a reversal in the head group dipole arrangement. Experiments were conducted using tryptophan as a fluorescent reporter of its local environment. Based on the experimental design in a recent publication ( Anderson , C. M. ; Cardenas , A. ; Elber , R. ; Webb , L. J. J. Phys. Chem. B 2018 , 123 , 170 - 179 ), we were able to determine that the arrangement of the head group dipole altered the degree of partitioning of charged tryptophan in the lipid bilayer. In parallel, atomically detailed simulations were performed for the two membrane systems. The simulation results are in accord with the experimental findings and support a simple molecular partition mechanism of electrostatic interactions with the head groups, glycerol linkers, and interfacial water dipoles.
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Registered trials
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