ArticleMolecular plant pathology2019
Hce2 domain-containing effectors contribute to the full virulence of Valsa mali in a redundant manner.
Article in Molecular plant pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Article
- Transcriptome sequencing reveals Vmplc1 involved in regulating the pathogenicity of Valsa Mali under low temperature induction.BMC genomics · 2025Article
- Roles of NADPH oxidases in regulating redox homeostasis and pathogenesis of the poplar canker fungus Cytospora chrysosperma.Stress biology · 2025Article
- A Novel Effector FoUpe9 Enhances the Virulence ofJournal of fungi (Basel, Switzerland) · 2025Article
- Highly Repetitive Genome ofInternational journal of molecular sciences · 2024Article
- Multi-Omics Approaches Provide New Insights into the Identification of Putative Fungal Effectors fromMicroorganisms · 2024Article
- Identification of propranolol and derivatives that are chemical inhibitors of phosphatidate phosphatase as potential broad-spectrum fungicides.Plant communications · 2024Article
- Pan-genome survey ofFrontiers in microbiology · 2024Article
- Small secreted effector protein from Fusarium sacchari suppresses host immune response by inhibiting ScPi21-induced cell death.Molecular plant pathology · 2024Article
- TheAutophagy · 2023Article
- Article
- Two NIS1-like proteins from apple canker pathogen (Valsa mali) play distinct roles in plant recognition and pathogen virulence.Stress biology · 2022Article
- The Transcription FactorFrontiers in microbiology · 2022Article
- Hydroxybenzoate hydroxylase genes underlying protocatechuic acid production in Valsa mali are required for full pathogenicity in apple trees.Molecular plant pathology · 2021Article
- Article
- Vm-milR37 contributes to pathogenicity by regulating glutathione peroxidase gene VmGP in Valsa mali.Molecular plant pathology · 2021Article
- Candidate Effectors fromInternational journal of molecular sciences · 2021Article
- AFrontiers in plant science · 2021Article
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7 authors.
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Abstract
Valsa mali is the causal agent of apple Valsa canker, a destructive disease in East Asia. Effector proteins play important roles in the virulence of phytopathogenic fungi, and we identified five Hce2 domain-containing effectors (VmHEP1, VmHEP2, VmHEP3, VmHEP4 and VmHEP5) from the V. mali genome. Amongst these, VmHEP1 and VmHEP2 were found to be up-regulated during the early infection stage and VmHEP1 was also identified as a cell death inducer through its transient expression in Nicotiana benthamiana. Although the deletion of each single VmHEP gene did not lead to a reduction in virulence, the double-deletion of VmHEP1 and VmHEP2 notably attenuated V. mali virulence in both apple twigs and leaves. An evolutionary analysis revealed that VmHEP1 and VmHEP2 are two paralogues, under purifying selection. VmHEP1 and VmHEP2 are located next to each other on chromosome 11 as tandem genes with only a 604 bp physical distance. Interestingly, the deletion of VmHEP1 promoted the expression of VmHEP2 and, vice versa, the deletion of VmHEP2 promoted the expression of VmHEP1. The present results provide insights into the functions of Hce2 domain-containing effectors acting as virulence factors of V. mali, and provide a new perspective regarding the contribution of tandem genes to the virulence of phytopathogenic fungi.
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