ArticleJournal of the American Heart Association2019
NT -pro BNP as a Mediator of the Racial Difference in Incident Atrial Fibrillation and Heart Failure.
Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Epidemiology of Asymptomatic Pre-heart Failure: a Systematic Review.Current heart failure reports · 2022Pooled it
- Sex and Racial Differences in Left Atrial Appendage Morphology.Journal of the American Heart Association · 2026Article
- Atrial to brain natriuretic peptide ratio as a marker of atrial remodeling severity and post-ablation recurrence risk in atrial fibrillation patients with left atrial enlargement.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Blocked Atrial Bigeminy as an Unusual Cause of Bradycardia: A Case Report.International medical case reports journal · 2025Article
- Towards improved detection of subclinical atrial fibrillation - Who could benefit from targeted screening?International journal of cardiology. Heart & vasculature · 2024Article
- Ethnic Differences in Atrial Fibrillation in the United Kingdom.JACC. Advances · 2024Article
- NT-pro-BNP Level is Related to Left Ventricular Remodeling in Patients With Primary Aldosteronism.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2024Article
- Predictive value of NT-proBNP, procalcitonin and CVP in patients with new-onset postoperative atrial fibrillation after cardiac surgery.American journal of translational research · 2022Article
- Serum FGF21 Levels Predict the MACE in Patients With Myocardial Infarction After Coronary Artery Bypass Graft Surgery.Frontiers in cardiovascular medicine · 2022Article
- Differences in Left Atrial Size and Function and Supraventricular Ectopy Between Black and White Participants in the ARIC Study.Journal of the American Heart Association · 2021Article
- Combining Biomarkers and Imaging for Short-Term Assessment of Cardiovascular Disease Risk in Apparently Healthy Adults.Journal of the American Heart Association · 2020Article
- Application of blood pre-albumin and NT-pro BNP levels in evaluating prognosis of elderly chronic heart failure patients.Experimental and therapeutic medicine · 2020Article
- Possible Mechanisms Underlying Elevated Serum N-Terminal Pro-Brain Natriuretic Peptide in Healthy Japanese Subjects.Circulation reports · 2019Article
- NT -pro BNP as a Mediator of the Racial Difference in Incident Atrial Fibrillation and Heart Failure.Journal of the American Heart Association · 2019Article
- Do the Natriuretic Peptides Cause Atrial Fibrillation or is it Not So Black and White?Journal of the American Heart Association · 2019Article
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Authors and funding
13 authors at 10 institutions in 1 country.
Funding
Abstract
Background Blacks harbor more cardiovascular risk factors than whites, but experience less atrial fibrillation ( AF ). Conversely, whites may have a lower risk of heart failure ( CHF ). N-terminal pro-B-type natriuretic peptide ( NT -pro BNP) levels are higher in whites, predict incident AF , and have diuretic effects in the setting of increased ventricular diastolic pressures, potentially providing a unifying explanation for these racial differences. Methods and Results We used data from the CHS (Cardiovascular Health Study) to determine the degree to which baseline NT -pro BNP levels mediate the relationships between race and incident AF and CHF by comparing beta estimates between models with and without NT -pro BNP . The ARIC (Atherosclerosis Risk in Communities) study was used to assess reproducibility. Among 4731 CHS (770 black) and 12 418 ARIC (3091 black) participants, there were 1277 and 1253 incident AF events, respectively. Whites had higher baseline NT -pro BNP ( CHS : 40% higher than blacks; 95% CI , 29-53; ARIC : 39% higher; 95% CI , 33-46) and had a greater risk of incident AF compared with blacks ( CHS : adjusted hazard ratio, 1.60; 95% CI , 1.31-1.93; ARIC : hazard ratio, 1.93; 95% CI , 1.57-2.27). NT -pro BNP levels explained a significant proportion of the racial difference in AF risk ( CHS : 36.2%; 95% CI , 23.2-69.2%; ARIC : 24.6%; 95% CI , 14.8-39.6%). Contrary to our hypothesis, given an increased risk of CHF among whites in CHS (adjusted hazard ratio, 1.20; 95% CI , 1.05-1.47) and the absence of a significant association between race and CHF in ARIC (adjusted hazard ratio, 1.07; 95% CI , 0.94-1.23), CHF -related mediation analyses were not performed. Conclusions A substantial portion of the relationship between race and AF was statistically explained by baseline NT -pro BNP levels. No consistent relationship between race and CHF was observed.
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