ArticleAsian Pacific journal of cancer prevention : APJCP2019
Pretreatment Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) as a Predictive Value of Hematological Markers in Cervical Cancer
Article in Asian Pacific journal of cancer prevention : APJCP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Neutrophil to lymphocyte ratio in odontogenic infection: a systematic review.Head & face medicine · 2024Pooled it
- Diagnostic and prognostic role of NLR in testicular cancer.Exploration of targeted anti-tumor therapy · 2024Pooled it
- Prognostic prediction of systemic immune-inflammation index for patients with gynecological and breast cancers: a meta-analysis.World journal of surgical oncology · 2020Pooled it
- Relationship between Neutrophil-to-Lymphocyte Ratio and Systemic Lupus Erythematosus: A Meta-analysis.Clinics (Sao Paulo, Brazil) · 2020Pooled it
- Routine Blood-Based Parameters Associated with Invasive Cervical Cancer Versus High-Grade Cervical Intraepithelial Neoplasia: Development of a Retrospective Diagnostic Prediction Model.Diagnostics (Basel, Switzerland) · 2026Article
- Hematological parameters as predictive indicators of disease stage in patients with cervical cancer.Scientific reports · 2026Article
- Mean platelet volume-to-albumin ratio as a predictor of pathological complete response in HER2-positive breast cancer undergoing neoadjuvant chemotherapy.Discover oncology · 2026Article
- Integrating neutrophil-to-lymphocyte ratio into cervical cancer management: implications for prognostic assessment and therapeutic strategies - a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Oxidative Stress and Cirrhosis Severity: A Retrospective Cohort Analysis of Predictive and Interactive Effects with Inflammation.Metabolites · 2025Article
- Pretreatment Systemic Inflammatory Markers, Neutrophil Lymphocyte Ratio, and Platelet Lymphocyte Ratio as a Prognostic Factor in Cervical Cancer: A Retrospective Study.South Asian journal of cancer · 2025Article
- The diagnostic significance of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in malaria: insights and implications - a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Risk Factors for Intrahepatic Distant Recurrence After Radiofrequency Ablation for Hepatocellular Carcinoma.Digestive diseases and sciences · 2025Article
- The Neutrophil-to-Lymphocyte Ratio (NLR) as a Potential Predictor in Conization Outcomes for Cervical Cancer.Cancers · 2025Article
- Haematology results, inflammatory haematological ratios, and inflammatory indices in cervical cancer: How is the difference between cancer stage?World journal of experimental medicine · 2025Article
- Article
- Association of albumin, neutrophil-lymphocyte ratio and lymphocytes with clinical stage in cervical cancer patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Role of hematological biomarkers in predicting oncological outcomes of definitive chemoradiation in locally advanced vulvar carcinoma.Journal of biological methods · 2025Article
- Pre-treatment blood parameters as an economical predictive marker for predicting treatment response in locally advanced cervical cancer.F1000Research · 2025Article
- Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery.Open medicine (Warsaw, Poland) · 2025Article
- Modulation of Chronic Cytokine Dysregulation in Cervical Cancer: Potential Biomarkers and Therapeutic Targets.Cancer management and research · 2025Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Inflammation represents a pivotal role in the progression of cervical cancer. The hematological markers of inflammation in complete blood count (CBC) panel are potentially useful in determining the prognosis of the disease. Objective: The aim of the study was to investigate whether the pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) could be used as in predicting the stage of cervical cancer. Methods: A retrospective cross-sectional study involving 282 patients with cervical cancer was enrolled at Sanglah General Hospital for five years (2013-2017). The histopathological records and complete blood counts (CBC) of the patients were collected and analyzed using SPSS ver. 16 software. FIGO stage I–II and III-IV were classified as early and advance stage respectively. Results: The median NLR and PLR were significantly higher in the advance stage compared with early stage (7.58 (1.36-33.20) and 247.89 (97.10-707.11); p-value = 0.001). A strong positive correlation was found between the staging of cervical cancer and NLR (r=0.638) and PLR (r=0.668). The AUC, sensitivity, and specificity value of NLR and PLR were 0.803 (82%; 71%) and 0.716 (72%; 70%). Advanced stage of cervical cancer was found in high NLR (adjusted OR: 9.02; 95%CI=2.42-33.64; p=0.001) and PLR (adjusted OR = 2.47; 95% CI = 1.45-4.85; p = 0.032). Conclusion: Increased pretreatment NLR and PLR values may provide a useful information in predicting the staging of cervical cancer.
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