ArticleAllergy, asthma & immunology research2019
Leukocyte Telomere Length Reflects Prenatal Stress Exposure, But Does Not Predict Atopic Dermatitis Development at 1 Year.
Article in Allergy, asthma & immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Association between telomere length and atopic dermatitis among school-age children.Clinical and translational allergy · 2025Article
- Maternal experience of intimate partner violence, maternal depression, and parental stress are not associated with child telomere length in Bangladesh.Scientific reports · 2025Article
- Prenatal maternal salivary hormones and timing of tooth eruption in early childhood: a prospective birth cohort study.Frontiers in oral health · 2025Article
- Immune-mediated inflammatory diseases and leukocyte telomere length: A Mendelian randomization study.Frontiers in genetics · 2023Article
- Prenatal exposure to maternal psychological distress and telomere length in childhood.Developmental psychobiology · 2022Article
- Maternal psychosocial functioning, obstetric health history, and newborn telomere length.Psychoneuroendocrinology · 2021Article
- The risk of preschool asthma at 2-4 years is not associated with leukocyte telomere length at birth or at 1 year of age.Asia Pacific allergy · 2019Article
- The association between intimate partner violence against women and newborn telomere length.Translational psychiatry · 2019Article
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 1 country.
Funding
Abstract
purposePrenatal maternal stress affects offspring's atopic dermatitis (AD) development, which is thought to be mediated by the oxidative stress. We aimed to evaluate the difference in leukocyte telomere length (LTL), a marker for exposure to oxidative stress, according to the prenatal stress exposure and the later AD development.
methodsFrom a birth cohort (the COhort for Childhood Origin of Asthma and allergic diseases) that had displayed a good epidemiologic association between the exposure to prenatal stress and AD development in the offspring, we selected 68 pairs of samples from 4 subject groups based on the level of prenatal maternal stress and later AD development. The LTL was measured from both cord blood and 1-year peripheral blood, and their LTLs were compared between subject groups. Finally, the proportion of AD development was examined in the subject groups that are reclassified based on subjects' exposure to prenatal stress and there LTL.
resultsCord-blood LTL was shorter in prenatally stressed infants than in unstressed ones (
conclusionsCord-blood LTL may reflect subjects' exposure to maternal prenatal stress. However, the LTL shortening is not a risk factor of increasing AD development until the age of 1, and a longer investigation may be necessary for validation. Currently, the results doubt the role of LTL shortening as a marker for risk assessment tool for the prenatal stress associated with AD development in the offspring.
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