ArticleCalcified tissue international1986
Osteoclastic features of cells that resorb bone implants in rats.
Article in Calcified tissue international, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 61 citations in OpenAlex.
- Hydroxyapatite particles are capable of inducing osteoclast formation.Journal of materials science. Materials in medicine · 2001Article
- Osteoclastic resorption of Ca-P biomaterials implanted in rabbit bone.Calcified tissue international · 1993Article
- Normal bone particles are preferentially resorbed in the presence of osteocalcin-deficient bone particles in vivo.Calcified tissue international · 1991Article
- Osteoclast formation is related to bone matrix age.Calcified tissue international · 1991Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
The subcutaneous implantation of devitalized, mineral-containing bone particles in rats elicits the recruitment and differentiation of multinucleated cells and the rapid resorption of the bone. Cytochemical and ultrastructural characteristics were studied 12 days after implantation of bone. Tartrate-resistant acid phosphatase activity was demonstrated in these cells, especially at the cell/bone interface. Mast cells were seen vicinal to, but not in contact with the osteoclasts and the bone particles. Electron microscopic evaluation revealed that many multinucleated cells in lacunae on the surfaces of the bone particles displayed features characteristic of in osso osteoclasts, including clear zones of attachment to the bone substrate, and ruffled borders overlying bone with frayed collagen fibers. Many cells contained multiple giant centrospheres; this finding suggests that fusion can occur between multinucleated cells. This model may be useful to characterize the differentiation and regulation of bone-resorbing cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.