Evidence map›Paper›PMID 30912231›Full record

Trial reportOral diseases2019

The influence of vitamin D supplementation on local and systemic inflammatory markers in periodontitis patients: A pilot study.

Mohamed M Meghil, Lance Hutchens, Anas Raed, Neha A Multani, Mythilypriya Rajendran, Haidong Zhu, Stephen Looney, Mahmoud Elashiry, Roger M Arce, Mark E Peacock and 2 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Oral diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Review
  7. The Role of Vitamin DNutrients · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Chronic Kidney Disease and Periodontitis Interplay-A Narrative Review.International journal of environmental research and public health · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Mohamed M MeghilDepartment of Periodontics, The Dental College of Georgia at Augusta University, Augusta, Georgia.ORCID https://orcid.org/0000-0003-2344-3579
Lance HutchensDepartment of Periodontics, The Dental College of Georgia at Augusta University, Augusta, Georgia.
Anas RaedGeorgia Prevention Institute, Augusta University, Augusta, Georgia.
Neha A MultaniDepartment of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, New York.
Mythilypriya RajendranDepartment of Periodontics, The Dental College of Georgia at Augusta University, Augusta, Georgia.
Haidong ZhuGeorgia Prevention Institute, Augusta University, Augusta, Georgia.
Stephen LooneyDepartment of Biostatistics and Epidemiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
Mahmoud ElashiryDepartment of Periodontics, The Dental College of Georgia at Augusta University, Augusta, Georgia.
Roger M ArceDepartment of Periodontics, The Dental College of Georgia at Augusta University, Augusta, Georgia.ORCID https://orcid.org/0000-0002-4721-4722
Mark E PeacockDepartment of Periodontics, The Dental College of Georgia at Augusta University, Augusta, Georgia.
Yanbin DongGeorgia Prevention Institute, Augusta University, Augusta, Georgia.
Christopher W CutlerDepartment of Periodontics, The Dental College of Georgia at Augusta University, Augusta, Georgia.
Augusta University · USEastman Chemical Company (United States) · US

Funding

Oral Pathogens and Dendritic Cell SubsetsR01DE014328 · NIDCR · STATE UNIVERSITY NEW YORK STONY BROOK · PI CUTLER, CHRISTOPHER WILLIAM · 2001 to 2014
$5.1M
Peripheral blood dendritic cells and periodontitisR21DE020916 · NIDCR · STATE UNIVERSITY NEW YORK STONY BROOK · PI CUTLER, CHRISTOPHER WILLIAM · 2011 to 2012
$362k
NIDCR NIH HHS R01 DE014328NIDCR NIH HHS R21 DE020916NIH/NIDCR R01 DE014328 [to CWC]The Carlos and Marguerite Mason trust
6 · The paper itself

Abstract

objectivesVitamin D deficiency/insufficiency is a worldwide public health issue that has been linked to numerous inflammatory disorders, including periodontitis. There is increasing support for a role for adequate vitamin D levels in overall health. Populations with darker skin color have a higher prevalence of vitamin D deficiency/insufficiency and periodontitis. The purpose of this small pilot study was to investigate the influence of 12 weeks of 25(OH)D vitamin D supplementation (VDS) on mediators of systemic inflammation in dark-skinned, periodontitis patients. MATERIALS AND

methodsA total of 23 patients with moderate to severe periodontitis were randomly assigned to the vitamin D group or placebo group and received intensive single visit scaling and root planning to elicit a systemic inflammatory response.

resultsVitamin D supplementation increased serum 25(OH)D levels approximately 2-fold over baseline levels; moreover, VDS group had reduced peripheral blood CD3 and CD3+CD8+ cytotoxic T lymphocyte (CTLs) counts and reduced pro-inflammatory salivary cytokines. In contrast, VDS group had higher levels of the autophagy-related proteins and other proteins crucial for anti-microbial autophagy in whole blood PBMCs.

conclusionIn conclusion, VDS has multiple benefits for reducing systemic inflammation and promoting induction of autophagy-related proteins related to anti-microbial functions.

Indexed as

PeriodontitisVitamin D DeficiencyDietary SupplementsHumansInflammationInflammation MediatorsPilot ProjectsVitamin DVitaminsInflammation MediatorsVitamin DVitaminsautophagyimmunityperiodontitissalivavitamin D

Identifiers

PMID30912231
PMCPMC8796207
OpenAlexW2924536613

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.