Evidence map›Paper›PMID 30912155›Full record

ArticlePacing and clinical electrophysiology : PACE2019

Patient characteristics as predictors of recurrence of atrial fibrillation following cryoballoon ablation.

Aakash A Bavishi, Rachel M Kaplan, Graham Peigh, Celso L Diaz, Jayson R Baman, Amar Trivedi, Jeremiah Wasserlauf, Mark J Shen, Prasongchai Sattayaprasert, Alexandru B Chicos and 6 more

Abstract read
In one paragraph

Article in Pacing and clinical electrophysiology : PACE, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Predicting recurrent atrial fibrillation after catheter ablation: a systematic review of prognostic models.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2020
    Pooled it
  2. Trial
  3. Modifiable Risk Factors in Atrial Fibrillation: Clinical Implications and Pathophysiological Insights.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026
    Review
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  14. Treatment success and its predictors as well as the complications of catheter ablation for atrial fibrillation in a high-volume centre.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2022
    Article
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  16. Observational
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  18. Evaluation of predictive scores for late and very late recurrence after cryoballoon-based ablation of atrial fibrillation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021
    Article
  19. Obstructive sleep apnea and atrial fibrillation: we need to go step by step.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Aakash A BavishiDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0003-3012-0380
Rachel M KaplanDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0003-0038-9231
Graham PeighDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0002-2388-8896
Celso L DiazDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Jayson R BamanDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0002-6214-5542
Amar TrivediDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Jeremiah WasserlaufDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Mark J ShenDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Prasongchai SattayaprasertDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Alexandru B ChicosDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Susan KimDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Nishant VermaDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Rishi AroraDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Albert LinDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Bradley P KnightDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0002-2129-0401
Rod S PassmanDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Northwestern University · US

Funding

Pathophysiological Significance of Atrial Fibrillation Electrogram PatternsR01HL125881 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARORA, RISHI · 2015 to 2019
$2.4M
Oxidative stress contributes to atrial fibrillation by causing remodeling of the autonomic nervous systemR01HL140061 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARORA, RISHI · 2018 to 2021
$2.3M
NHLBI NIH HHS R01 HL125881NHLBI NIH HHS R01 HL140061
6 · The paper itself

Abstract

backgroundWhile several studies have evaluated predictors for atrial fibrillation (AF) recurrence following catheter ablation, there are limited data specific to cryoballoon ablation (CBA).

methodsWe analyzed a prospective registry of patients at a single institution who underwent CBA. Recurrence of AF (RAF) was defined as recurrence of AF by 12-month follow-up, excluding the 3-month blanking period. Univariate analysis was performed to evaluate predictors of RAF. Receiver operating characteristic analysis was used to compare and evaluate the performance of various risk scores for discriminating risk of RAF.

resultsThere were 542 patients included in the analysis with mean age 61.3 ± 10.6 years, 67.9% male, and 51.6% paroxysmal AF (PAF). Overall, only left atrial diameter (LAD) > 40 mm and ERAF (early recurrence of AF within 0-3 month blanking period) were significant predictors of RAF. In the PAF specific subgroup, LAD > 40 mm, AF duration > 12 months, prior stroke or transient ischemic attack, ERAF, and having previously failed an antiarrhythmic drug were significant predictors of RAF. In persistent AF (PeAF) subgroup, obstructive sleep apnea (OSA) and ERAF were significant predictors of RAF. Out of clinical risk scores tested, BASEAF2 had the highest performance with area under the curve of 0.646 (95% confidence interval [0.548, 0.708]; P < .01).

conclusionsIn this single-center retrospective study of CBA, we found only LAD > 40 mm and ERAF to be predictors of RAF. We identified OSA as a potential targetable risk factor in PeAF patients undergoing CBA. Out of risk scores tested for discriminating risk of RAF, BASEAF2 had the best performance.

Indexed as

AgedAnti-Arrhythmia AgentsAtrial FibrillationCryosurgeryFemaleFollow-Up StudiesHumansIschemic Attack, TransientMaleMiddle AgedRecurrenceRetrospective StudiesRisk FactorsSleep Apnea, ObstructiveStrokeTime FactorsAnti-Arrhythmia Agentsatrial fibrillationcryoballoon ablation

Identifiers

PMID30912155
PMCPMC7025864
OpenAlexW2924444593

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.