Evidence map›Paper›PMID 30912146›Full record

ArticleJournal of cellular physiology2019

Hydrogen sulfide attenuates homocysteine-induced osteoblast dysfunction by inhibiting mitochondrial toxicity.

Yuankun Zhai, Jyotirmaya Behera, Suresh C Tyagi, Neetu Tyagi

Open access · greenAbstract read
In one paragraph

Article in Journal of cellular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

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  12. Association of Hydrogen Sulfide with Femoral Bone Mineral Density in Osteoporosis Patients: A Preliminary Study.Medical science monitor : international medical journal of experimental and clinical research · 2021
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  13. Review
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  16. Hydrogen sulfide signaling in mitochondria and disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yuankun ZhaiDepartment of Physiology, School of Medicine, University of Louisville, Louisville, Kentucky.ORCID 0000-0001-8156-1368
Jyotirmaya BeheraDepartment of Physiology, School of Medicine, University of Louisville, Louisville, Kentucky.
Suresh C TyagiDepartment of Physiology, School of Medicine, University of Louisville, Louisville, Kentucky.ORCID 0000-0002-4574-4850
Neetu TyagiDepartment of Physiology, School of Medicine, University of Louisville, Louisville, Kentucky.ORCID 0000-0003-0285-5072
University of Louisville · US

Funding

Mitigating mitochondrial epigenetics in bone remodeling by hydrogen sulfideR01AR067667 · NIAMS · UNIVERSITY OF LOUISVILLE · PI TYAGI, NEETU, TYAGI, SURESH C. · 2015 to 2019
$2.5M
Reversing Skeletal Muscle Myopathy by Hydrogen SulfideR01AR071789 · NIAMS · UNIVERSITY OF LOUISVILLE · PI TYAGI, SURESH C. · 2018 to 2023
$1.7M
NIAMS NIH HHS R01 AR067667NIAMS NIH HHS R01 AR071789
6 · The paper itself

Abstract

Homocysteine (Hcy) is detrimental to bone health in a mouse model of diet-induced hyperhomocysteinemia (HHcy). However, little is known about Hcy-mediated osteoblast dysfunction via mitochondrial oxidative damage. Hydrogen sulfide (H

Indexed as

AnimalsApoptosisCalcification, PhysiologicCell LineCell SurvivalHomocysteineHydrogen SulfideMice, Inbred C57BLMitochondriaOsteoblastsOsteogenesisOxidative StressReactive Oxygen SpeciesHomocysteineHydrogen SulfideReactive Oxygen Specieshydrogen sulfidemethioninemitochondriaosteoblastoxidative stress

Identifiers

PMID30912146
PMCPMC6719545
OpenAlexW2922694041

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.