Evidence map›Paper›PMID 30912057›Full record

ArticleJournal of endocrinological investigation2019

Thyroid function in Klinefelter syndrome: a multicentre study from KING group.

G Balercia, M Bonomi, V A Giagulli, F Lanfranco, V Rochira, A Giambersio, G Accardo, D Esposito, S Allasia, B Cangiano and 5 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

G BalerciaDivision of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Ancona, Italy.
M BonomiDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
V A GiagulliOutpatient Clinic for Endocrinology and Metabolic Diseases, Conversano Hospital, Conversano, Bari, Italy.
F LanfrancoDivision of Endocrinology, Diabetology, and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy.
V RochiraUnit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
A GiambersioHealt Center "Maria Teresa Di Calcutta, Potenza, Italy.
G AccardoDepartment of Advanced Medical And Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy.
D EspositoDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
S AllasiaDivision of Endocrinology, Diabetology, and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy.
B CangianoDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
S De VincentisUnit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
R A CondorelliDepartment of Clinical and Experimental Medicine, University of Catania, Policlinico "G. Rodolico", Catania, Italy.
A CalogeroDepartment of Clinical and Experimental Medicine, University of Catania, Policlinico "G. Rodolico", Catania, Italy.
D PasqualiDepartment of Advanced Medical And Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy. daniela.pasquali@unicampania.it.
KING group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe prevalence and the etiopathogenesis of thyroid dysfunctions in Klinefelter syndrome (KS) are still unclear. The primary aim of this study was to evaluate the pathogenetic role of hypogonadism in the thyroid disorders described in KS, with the scope to distinguish between patients with KS and hypogonadism due to other causes (Kallmann syndrome, idiopathic hypogonadotropic hypogonadism, iatrogenic hypogonadism and acquired hypogonadotropic hypogonadism after surgical removal of pituitary adenomas) called non-KS. Therefore, we evaluated thyroid function in KS and in non-KS hypogonadal patients.

methodsThis is a case-control multicentre study from KING group: Endocrinology clinics in university-affiliated medical centres. One hundred and seventy four KS, and sixty-two non-KS hypogonadal men were enrolled. The primary outcome was the prevalence of thyroid diseases in KS and in non-KS. Changes in hormonal parameters were evaluated. Exclusion criterion was secondary hypothyroidism. Analyses were performed using Student's t test. Mann-Whitney test and Chi-square test.

resultsFT4 was significantly lower in KS vs non-KS. KS and non-KS presented similar TSH and testosterone levels. Hashimoto's thyroiditis (HT) was diagnosed in 7% of KS. Five KS developed hypothyroidism. The ratio FT3/FT4 was similar in both groups. TSH index was 1.9 in KS and 2.3 in non-KS. Adjustment for differences in age, sample size and concomitant disease in multivariate models did not alter the results.

conclusionsWe demonstrated in KS no etiopathogenic link to hypogonadism or change in the set point of thyrotrophic control in the altered FT4 production. The prevalence of HT in KS was similar to normal male population, showing absence of increased risk of HT associated with the XXY karyotype.

Indexed as

Academic Medical CentersAdolescentAdultAgedCase-Control StudiesFemaleHashimoto DiseaseHumansHypogonadismItalyKlinefelter SyndromeMaleMiddle AgedThyroid DiseasesThyroid Function TestsThyroid GlandThyroid HormonesThyrotropinHashimoto’s thyroiditisHypergonadotropic hypogonadismKlinefelter syndromeTestosteroneThyroid diseasesThyroid hormones

Identifiers

PMID30912057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.