ArticleWorld journal of pediatrics : WJP2019
Clinical characteristics and beta-cell function of Chinese children and adolescents with type 2 diabetes from 2009 to 2018.
Article in World journal of pediatrics : WJP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 14 citations in OpenAlex.
- Capillary Glycated Hemoglobin A1c Percentiles and the Risk Factors Associated with Abnormal HbA1c among Chinese Children Aged 3-12 Years.Pediatric diabetes · 2024Article
- Dietary Fiber Intake May Influence the Impact ofAntioxidants (Basel, Switzerland) · 2021Article
- Association of β-cell function and insulin resistance with pediatric type 2 diabetes among Chinese children.World journal of diabetes · 2021Article
- The Impact ofNutrients · 2020Article
- The Impact of Diabetes Mellitus on Cardiovascular Risk Onset in Children and Adolescents.International journal of molecular sciences · 2020Review
- Sex differences in the burden of type 2 diabetes and cardiovascular risk across the life course.Diabetologia · 2019Review
- Big challenges: obesity and type 2 diabetes in children and adolescents.World journal of pediatrics : WJP · 2019Article
- Working memory characteristics in T2DM individuals with MMSE-defined cognitive status: a behavioral study.Frontiers in neurologyArticle
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
backgroundThe limited available studies have unveiled different natural histories and prognosis associated with pediatric type 2 diabetes (T2D) and adult T2D. To date, data on the clinical features, metabolic profiles and beta-cell function characteristics are still limited in the Chinese pediatric T2D population.
methodsA total of 56 children with T2D, 31 with prediabetes and 159 with obesity were recruited. Clinical characteristics, metabolic profiles, beta-cell function and insulin resistance were analyzed.
resultsThe mean onset age of T2D was 12.35 ± 1.99 (7.9-17.8) years, and 7% of children were younger than 10 years; 55% of them were male, 57% had a family history of diabetes and 64% had classic symptoms, and 25% had a low or high birth weight. 89% of T2D patients were obese or overweight. A total of 58% of the patients with prediabetes were male. The fast serum C-peptide level was highest in the obesity group (P < 0.001), and there was no significant difference between the T2D and prediabetes groups. The mean homeostatic model of assessment of beta-cell function was the highest in the obesity group and was lowest in the T2D group (P < 0.001). The T2D group had the most serious lipid metabolism disorder, with the highest levels of total triglycerides, total cholesterol, and low density lipoprotein and the lowest high density lipoprotein level among the three groups.
conclusionsA younger onset age and greater male susceptibility were found in Chinese pediatric T2D patients, and there was a stepwise deterioration trend in beta-cell function among patients with obesity, prediabetes and T2D. Based on our results, together with the SEARCH study results, an early screening and intervention program for T2D is recommended in high-risk or obese Chinese pediatric populations starting at 7 years.
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