ArticleMolecular biology reports2019
Long non-coding RNA SNHG6 is upregulated in prostate cancer and predicts poor prognosis.
Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Prognostic and clinicopathological significance of SNHG6 in human cancers: a meta-analysis.BMC cancer · 2020Pooled it
- Up-regulation of intra-tumour LDLR gene expression is associated with statin treatment and better prostate cancer prognosis.Acta oncologica (Stockholm, Sweden) · 2025Article
- LncRNA SNHG6 role in clinicopathological parameters in cancers.European journal of medical research · 2023Review
- SNHG6 203 RNA May be Involved in the Cell Cycle Progression in HER2-Negative Breast Cancer Cells.Iranian journal of pathology · 2022Article
- Article
- Long Noncoding RNA Small Nucleolar Host Gene: A Potential Therapeutic Target in Urological Cancers.Frontiers in oncology · 2021Review
- LncRNA SNHG6 promotes LMO3 expression by sponging miR-543 in glioma.Molecular and cellular biochemistry · 2020Article
- Long non-coding RNA small nucleolar RNA host gene 6 aggravates pancreatic cancer through upregulation of far upstream element binding protein 1 by sponging microRNA-26a-5p.Chinese medical journal · 2020Article
- Long Non-Coding Small Nucleolar RNA Host Genes (SNHGs) in Endocrine-Related Cancers.OncoTargets and therapy · 2020Review
- Long Noncoding RNA SNHG6 Functions as an Oncogene in Non-Small Cell Lung Cancer via Modulating ETS1 Signaling.OncoTargets and therapy · 2020Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Certain long non-coding RNAs (lncRNAs) have been reported to be differentially expressed in various human cancer types, including prostate cancer (PCa). PCa is the most commonly diagnosed cancer type in men and lacks sensitive and accurate biomarkers. Emerging studies have indicated that certain lncRNAs are dysregulated and have crucial roles in PCa progression. The present study reported that the novel lncRNA small nucleolar RNA host gene 6 (SNHG6) is overexpressed in PCa compared with that in normal prostate tissues. In The Cancer Genome Atlas and Taylor datasets, high expression of SNHG6 in PCa tissues was identified to be significantly associated with shorter disease-free survival. In order to reveal the potential mechanisms of the role of SNHG6 in PCa, SNHG6-associated protein-protein interaction networks were constructed. Bioinformatics analysis revealed that these SNHG6-interacting genes were associated with translation, nuclear-transcribed mRNA catabolic process, ribosomal RNA processing and mRNA splicing. Although further functional validation is warranted, the present study suggests that SNHG6 is a potential novel therapeutic target and prognostic biomarker for PCa.
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