Evidence map›Paper›PMID 30911972›Full record

ReviewMolecular biology reports2019

Functions of RNA N6-methyladenosine modification in cancer progression.

Bing Chen, Ya Li, Ruifeng Song, Chen Xue, Feng Xu

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Article
  3. Clinical significance of RNA methylation in hepatocellular carcinoma.Cell communication and signaling : CCS · 2024
    Review
  4. Non-coding RNA-Mediated N6-Methyladenosine (mNon-coding RNA research · 2024
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Gene signature and prognostic merit of M6a regulators in colorectal cancer.Experimental biology and medicine (Maywood, N.J.) · 2020
    Article
  17. Article
  18. NMolecular therapy. Nucleic acids · 2020
    Review
  19. Article
  20. Hypoxia promotes proliferation of pituitary adenomas by HIF-1α/ALKBH5 signalingInternational journal of clinical and experimental pathology · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Bing ChenDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Eastern Road, Zhengzhou, 450052, People's Republic of China.
Ya LiDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Eastern Road, Zhengzhou, 450052, People's Republic of China.
Ruifeng SongDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Eastern Road, Zhengzhou, 450052, People's Republic of China.
Chen XueDepartment of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Eastern Road, Zhengzhou, 450052, People's Republic of China.
Feng XuDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Eastern Road, Zhengzhou, 450052, People's Republic of China. fccxuf@zzu.edu.cn.

Funding

The Key Project of Scientific Research Foundation for Colleges and Universities in Henan Province 16A320081The National Natural Science Foundation of China 81802325
6 · The paper itself

Abstract

N6-methyladenosine (m6A) serves as a major RNA methylation modification and impacts the initiation and progression of various human cancers through diverse mechanisms. It has been reported that m6A RNA methylation is involved in different physiological and pathological processes, including stem cell differentiation and motility, immune response, cellular stress, tissue renewal and viral infection. In this review, the m6A modification and its regulatory functions in a few major cancers is introduced. The detection approaches for the m6A sites identification are discussed. Additionally, the potential of the RNA m6A modification in clinical application is discussed.

Indexed as

AdenosineDisease ProgressionHumansMethylationMethyltransferasesNeoplasmsRNARNA Processing, Post-TranscriptionalAdenosineMethyltransferasesN-methyladenosineRNACancer progressionClinical applicationDetection approachesPhysiological and pathological processesRNA N6-methyladenosine modification

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.