Evidence map›Paper›PMID 30911952›Full record

ArticleJournal of the Association for Research in Otolaryngology : JARO2019

The Estimated Electrode-Neuron Interface in Cochlear Implant Listeners Is Different for Early-Implanted Children and Late-Implanted Adults.

Mishaela DiNino, Gabrielle O'Brien, Steven M Bierer, Kelly N Jahn, Julie G Arenberg

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Association for Research in Otolaryngology : JARO, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Machine learning model for automated calculation of intracochlear positional index in cochlear implantation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Cochlear Health and Cochlear-implant Function.Journal of the Association for Research in Otolaryngology : JARO · 2023
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Effects of Age and Cochlear Implantation on Spectrally Cued Speech Categorization.Journal of speech, language, and hearing research : JSLHR · 2020
    Article
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mishaela DiNinoDepartment of Psychology, Carnegie Mellon University, 5000 Forbes, Ave., Pittsburgh, PA, 15213, USA. mdinino@andrew.cmu.edu.ORCID 0000-0001-5623-3020
Gabrielle O'BrienDepartment of Speech and Hearing Sciences, University of Washington, 1417 NE 42nd St., Box 354875, Seattle, WA, 98105, USA.
Steven M BiererDepartment of Speech and Hearing Sciences, University of Washington, 1417 NE 42nd St., Box 354875, Seattle, WA, 98105, USA.
Kelly N JahnDepartment of Speech and Hearing Sciences, University of Washington, 1417 NE 42nd St., Box 354875, Seattle, WA, 98105, USA.
Julie G ArenbergDepartment of Otolaryngology, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles St., Boston, MA, 02114, USA.

Funding

Auditory Neuroscience Traning ProgramT32DC005361 · NIDCD · UNIVERSITY OF WASHINGTON · PI Adrian KC Lee, DAVID J PERKEL · 2002 to 2026
$8.8M
Perceptual implications of cochlear implant electrode-neuron interfacesR01DC012142 · NIDCD · UNIVERSITY OF WASHINGTON · PI JULIE G Arenberg · 2012 to 2026
$6.5M
NIDCD NIH HHS R01 DC012142NIDCD NIH HHS T32 DC005361
6 · The paper itself

Abstract

Cochlear implant (CI) programming is similar for all CI users despite limited understanding of the electrode-neuron interface (ENI). The ENI refers to the ability of each CI electrode to effectively stimulate target auditory neurons and is influenced by electrode position, neural health, cochlear geometry, and bone and tissue growth in the cochlea. Hearing history likely affects these variables, suggesting that the efficacy of each channel of stimulation differs between children who were implanted at young ages and adults who lost hearing and received a CI later in life. This study examined whether ENI quality differed between early-implanted children and late-implanted adults. Auditory detection thresholds and most comfortable levels (MCLs) were obtained with monopolar and focused electrode configurations. Channel-to-channel variability and dynamic range were calculated for both types of stimulation. Electrical field imaging data were also acquired to estimate levels of intracochlear resistance. Children exhibited lower average auditory perception thresholds and MCLs compared with adults, particularly with focused stimulation. However, neither dynamic range nor channel-to-channel threshold variability differed between groups, suggesting that children's range of perceptible current was shifted downward. Children also demonstrated increased intracochlear resistance levels relative to the adult group, possibly reflecting greater ossification or tissue growth after CI surgery. These results illustrate physical and perceptual differences related to the ENI of early-implanted children compared with late-implanted adults. Evidence from this study demonstrates a need for further investigation of the ENI in CI users with varying hearing histories.

Indexed as

Cochlear ImplantationCochlear ImplantsAdolescentAgedAged, 80 and overAge FactorsChildHumansMiddle AgedSpiral Ganglionchildrencochlear implantdynamic rangeelectrical field imagingimpedancethreshold

Identifiers

PMID30911952
PMCPMC6513958

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.