ReviewRheumatology international2019
Modifiable risk factors in knee osteoarthritis: treatment implications.
Review in Rheumatology international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
111 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Association of low muscle mass index and sarcopenic obesity with knee osteoarthritis: a systematic review and meta-analysis.Journal of the International Society of Sports Nutrition · 2024Pooled it
- Just-in-Time Adaptive Interventions for Behavior Change in Physiological Health Outcomes and the Use Case for Knee Osteoarthritis: Systematic Review.Journal of medical Internet research · 2024Pooled it
- Causal analysis of body composition measurements in osteoarthritis knee: a two-sample mendelian randomization study.BMC musculoskeletal disorders · 2024Pooled it
- The association between alcohol consumption and osteoarthritis: a meta-analysis and meta-regression of observational studies.Rheumatology international · 2021Pooled it
- Efficacy of high intensity laser therapy versus sham laser in symptomatic knee osteoarthritis: a double-blind randomized controlled trial.Lasers in medical science · 2025Trial
- Effect of prebiotic fiber on physical function and gut microbiota in adults, mostly women, with knee osteoarthritis and obesity: a randomized controlled trial.European journal of nutrition · 2024Trial
- [Functionality/isokinetic work of quadriceps in patients with gonarthrosis managed with prolotherapy].Revista medica del Instituto Mexicano del Seguro Social · 2023Trial
- Predicting Knee osteoarthritis progression using explainable machine learning and clinical imaging data.Osteoarthritis and cartilage open · 2026Article
- Intra-Articular Steroid Injection with or Without Pulsed Radiofrequency in Knee Osteoarthritis: A Retrospective Comparative Study.Medicina (Kaunas, Lithuania) · 2026Article
- Tibial genu varum and primary cam morphology in healthy young adults: A cross-sectional study uncovering the double threat to joint health.Osteoarthritis and cartilage open · 2026Article
- Anti-inflammatory and osteogenic effects of transcutaneous electrical nerve stimulation in knee osteoarthritis rats via the regulation of the intestinal microbiota.Animal models and experimental medicine · 2026Article
- Partial bodyweight-supported squats elicit eccentric contraction of the thigh muscles.BMC musculoskeletal disorders · 2026Article
- Article
- Review
- Investigating predictors of pain events during trials of knee osteoarthritis: A post-hoc analysis of two phase III trials.Osteoarthritis and cartilage open · 2026Article
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- Article
- The global profile of individuals undergoing total knee replacement surgery through a PROGRESS-PLUS equity lens: A systematic review.The South African journal of physiotherapy · 2026Review
- Prevalence of radiographic knee osteoarthritis in China: a national survey of thirty thousand, four hundred and fifty five individuals cross-sectional study.International orthopaedics · 2025Article
- Relationship of total and regional lean body mass with knee pain and function in patients with knee osteoarthritis: a cross-sectional study.BMC musculoskeletal disorders · 2025Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optimal management of knee osteoarthritis (KOA) should include, where possible, modification of risk factors through targeted interventions. The objectives of the present narrative review were to identify, summarize, and cluster all the potentially modifiable risk factors that influence the course of KOA, and discuss their susceptibility to alteration via personal, clinical, and public strategy. For this purpose, Pubmed and Scopus databases were queried using the terms "knee osteoarthritis", "risk factors" and "improvement". Six main categories of modifiable risk factors were identified: (1) obesity and overweight, (2) comorbidity, (3) occupational factors, (4) physical activity, (5) biomechanical factors, (6) dietary exposures. In the era of age- and obesity-related diseases, the combined effects of local and systemic risk factors should be managed by combined measures. Femoral muscle-strengthening physical activities, complemented with proper diet, weight loss, vocational rehabilitation, management of comorbidities (especially diabetes and depression), and biomechanical support may add up to the holistic therapeutic approach towards the patient with KOA. An individual risk factor modification program should be developed in accordance with patient preferences and habits, workplace, medical history, and overall health condition. Due to its great impact on a wide range of functions and tissues, interventions on modifiable risk factors improve not only the symptoms of KOA but also affect the osteoarthritic joint as a whole.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.