Evidence map›Paper›PMID 30911804›Full record

ArticleIntensive care medicine2019

ESICM/ESCMID task force on practical management of invasive candidiasis in critically ill patients.

Ignacio Martin-Loeches, Massimo Antonelli, Manuel Cuenca-Estrella, George Dimopoulos, Sharon Einav, Jan J De Waele, Jose Garnacho-Montero, Souha S Kanj, Flavia R Machado, Philippe Montravers and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Intensive care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 2 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 2 syntheses or guidelines pooled it, 232 citations in OpenAlex.

  1. [S3 guideline on sepsis-prevention, diagnosis, therapy, and follow-up care-update 2025].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025
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  15. Differences in Clinical Characteristics of AECOPD Patients with or withoutInternational journal of chronic obstructive pulmonary disease · 2026
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70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 13 institutions in 10 countries.

Ignacio Martin-LoechesMultidisciplinary Intensive Care Research Organization (MICRO), St. James's Hospital, Dublin, Ireland. drmartinloeches@gmail.com.ORCID 0000-0002-5834-4063
Massimo AntonelliDepartment of Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Manuel Cuenca-EstrellaCentro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
George DimopoulosDepartment of Critical Care, University Hospital ATTIKON, National and Kapodistrian University of Athens, Athens, Greece.
Sharon EinavGeneral Intensive Care Unit, Shaare Zedek Medical Centre and the Hebrew University Faculty of Medicine, Jerusalem, Israel.
Jan J De WaeleDepartment of Critical Care Medicine, Ghent University Hospital, Ghent, Belgium.
Jose Garnacho-MonteroIntensive Care Clinical Unit, Hospital Universitario Virgen Macarena, Seville, Spain.
Souha S KanjDivision of Infectious Diseases, American University of Beirut Medical Center, Beirut, Lebanon.
Flavia R MachadoAnesthesiology, Pain and Intensive Care Department, Federal University of Sao Paulo, Sao Paulo, Brazil.
Philippe MontraversParis Diderot, Sorbonne Cite University, and Anaesthesiology and Critical Care Medicine, Bichat-Claude Bernard University Hospital, HUPNSV, AP-HP, INSERM, UMR 1152, Paris, France.
Yasser SakrDepartment of Anesthesiology and Intensive Care, Uniklinikum Jena, Jena, Germany.
Maurizio SanguinettiFondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Institute of Microbiology, Rome, Italy.
Jean-Francois TimsitUMR 1137, IAME Inserm/University Paris Diderot, Paris, France.
Matteo BassettiInfectious Diseases Clinic, Department of Medicine University of Udine and Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy.
Università Cattolica del Sacro Cuore · ITAmerican University of Beirut Medical Center · LBGhent University Hospital · BEHospital Clínic de Barcelona · ESHospital Universitario Virgen Macarena · ESInserm · FRInstituto de Salud Carlos III · ESJena University Hospital · DENational and Kapodistrian University of Athens · GRShaare Zedek Medical Center · ILUniversidade Federal de São Paulo · BRUniversité Claude Bernard Lyon 1 · FRUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe term invasive candidiasis (IC) refers to both bloodstream and deep-seated invasive infections, such as peritonitis, caused by Candida species. Several guidelines on the management of candidemia and invasive infection due to Candida species have recently been published, but none of them focuses specifically on critically ill patients admitted to intensive care units (ICUs). MATERIAL AND

methodsIn the absence of available scientific evidence, the resulting recommendations are based solely on epidemiological and clinical evidence in conjunction with expert opinion. The task force used the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach to evaluate the recommendations and assign levels of evidence. The recommendations and their strength were decided by consensus and, if necessary, by vote (modified Delphi process). Descriptive statistics were used to analyze the results of the Delphi process. Statements obtaining > 80% agreement were considered to have achieved consensus.

conclusionsThe heterogeneity of this patient population necessitated the creation of a mixed working group comprising experts in clinical microbiology, infectious diseases and intensive care medicine, all chosen on the basis of their expertise in the management of IC and/or research methodology. The working group's main goal was to provide clinicians with clear and practical recommendations to optimize microbiological diagnosis and treatment of IC. The Systemic Inflammation and Sepsis and Infection sections of the European Society of Intensive Care Medicine (ESICM) and the Critically Ill Patients Study Group of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) therefore decided to develop a set of recommendations for application in non-immunocompromised critically ill patients.

Indexed as

Disease ManagementAntifungal AgentsCandidiasis, InvasiveCritical IllnessDelphi TechniqueEchinocandinsFluconazoleHumansIntensive Care UnitsSepsisAntifungal AgentsEchinocandinsFluconazoleAntifungalEchinocandinFluconazoleFungalSepsisShock

Identifiers

PMID30911804
OpenAlexW2941512894

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.