ArticlePleura and peritoneum2017
Peritoneal innervation: embryology and functional anatomy.
Article in Pleura and peritoneum, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06120530 (Effect of Intraperitoneal Bupivacaine on Postoperative Pain Control in Patients Undergoing Pelvic Organ Prolapse Repair), which is not on this map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Intraperitoneal Bupivacaine on Postoperative Pain Control in Patients Undergoing Pelvic Organ Prolapse Repair
Who cites it
25 citing papers in PubMed, 72 citations in OpenAlex.
- Preperitoneal analgesia under direct visualization: laparoscopic-guided deep rectus sheath block improves postoperative pain control after laparoscopic cholecystectomy: a randomized controlled trial.Surgical endoscopy · 2026Trial
- Efficacy of Quadratus Lumborum Block for Postoperative Pain Management in Single-Port Total Laparoscopic Hysterectomy: A Randomized Observer-Blinded Controlled Trial.Medicina (Kaunas, Lithuania) · 2025Trial
- The peritoneum in perspective: extracellular vesicles and the future of peritoneal dialysis.Renal failure · 2026Review
- Paravertebral blocks for post-operative analgesia for robotic-assisted partial nephrectomy: a retrospective review.Translational andrology and urology · 2026Article
- In Search of Ideal Analgesia: Classical and Deep Rectus Sheath Block in Laparoscopic Cholecystectomy.Local and regional anesthesia · 2026Review
- Revisiting the deep rectus sheath block: An anatomical mismatch for optimal analgesia.Indian journal of anaesthesia · 2025Article
- Deep rectus sheath block: A novel pain management approach after laparoscopic cholecystectomy - A case study.Indian journal of anaesthesia · 2025Article
- Minimally Painful Tumescent Local Anesthesia for Wide-awake Javid Loop Colostomy Reversal.Plastic and reconstructive surgery. Global open · 2025Article
- Perioperative analgesic efficacy of quadratus lumborum block versus transversus abdominis plane block in dogs undergoing laparoscopic ovariectomy: a prospective randomized clinical trial.Frontiers in veterinary science · 2025Article
- HELLP syndrome and associated factors among pregnant women with preeclampsia/eclampsia at a referral hospital in southwestern Uganda: a cross-sectional study.BMC pregnancy and childbirth · 2024Article
- Review
- Phrenic nerve block: the key to managing acute biliary pain?World journal of emergency medicine · 2024Article
- Review
- Review
- From transabdominal to totally extra-peritoneal robotic ventral hernia repair: observations and outcomes.Hernia : the journal of hernias and abdominal wall surgery · 2023Article
- Local Anesthesia in Interventional Radiology.Seminars in interventional radiology · 2022Review
- Robotic-assisted laparoscopic hysterectomy and vasovagal reflex: A case report.Clinical case reports · 2022Article
- Nociceptors: Their Role in Body's Defenses, Tissue Specific Variations and Anatomical Update.Journal of pain research · 2022Review
- Massive Acquired Renal Cysts Presenting with Bowel Obstruction-Like Symptoms.Case reports in medicine · 2022Article
- Peripheral, Central, and Cross Sensitization in Endometriosis-Associated Pain and Comorbid Pain Syndromes.Frontiers in reproductive health · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The parietal peritoneum (PP) is innervated by somatic and visceral afferent nerves. PP receives sensitive branches from the lower intercostal nerves and from the upper lumbar nerves. Microscopically, a dense network of unmyelinated and myelinated nerve fibers can be found all over the PP. The unmyelinated fibers are thin and are ending just underneath the PP. The myelinated fibers can penetrate the PP to reach the peritoneal cavity, where they lose their myelin sheath and are exposed to somatic and nociceptive stimuli. PP is sensitive to pain, pressure, touch, friction, cutting and temperature. Noxious stimuli are perceived as a localized, sharp pain. The visceral peritoneum (VP) itself is not innervated, but the sub-mesothelial tissue is innervated by the autonomous nerve system. In contrast to the PP, the visceral submesothelium also receives fibers from the vagal nerve, in addition to the spinal nerves. VP responds primarily to traction and pressure; not to cutting, burning or electrostimulation. Painful stimuli of the VP are poorly localized and dull. Pain in a foregut structure (stomach, duodenum or biliary tract) is referred to the epigastric region, pain in a midgut structure (appendix, jejunum, or ileum) to the periumbilical area and pain from a hindgut source (distal colon or rectum) is referred to the lower abdomen or suprapubic region. Peritoneal adhesions can contain nerve endings. Neurotransmitters are acetylcholine, VIP, serotonin, NO, encephalins, CGRP and substance P. Chronic peritoneal pain can be exacerbated by neurogenic inflammation, e.g. by endometriosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.