ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019
Breadth and depth of working memory and executive function compromises in mild cognitive impairment and their relationships to frontal lobe morphometry and functional competence.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Exploring the impact of intensified multiple session tDCS over the left DLPFC on brain function in MCI: a randomized control trial.Scientific reports · 2024Trial
- Blood-Based Biomarkers Predict Differential Longitudinal Decline in Alzheimer's Disease Psychosis: Evidence from Two Cohorts.medRxiv : the preprint server for health sciences · 2026Article
- Novel measures of cognition and function for the AD spectrum in the Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD) project: Psychometric properties, convergent validation, and contrasts with established measures.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cognitive function based on theta-gamma coupling vs. clinical diagnosis in older adults with mild cognitive impairment with or without major depressive disorder.Translational psychiatry · 2024Article
- Cognitive, Emotional, and Daily Functioning Domains Involved in Decision-Making among Patients with Mild Cognitive Impairment: A Systematic Review.Brain sciences · 2024Review
- Brain volumetric changes in menopausal women and its association with cognitive function: a structured review.Frontiers in aging neuroscience · 2023Review
- Alterations of neural activity in the prefrontal cortex associated with deficits in working memory performance.Frontiers in behavioral neuroscience · 2023Review
- Higher-Level Executive Functions in Healthy Elderly and Mild Cognitive Impairment: A Systematic Review.Journal of clinical medicine · 2022Review
- REM Sleep Behavior Disorder in Parkinson's Disease: Change in Cognitive, Psychiatric, and Functional Outcomes from Baseline to 16-47-Month Follow-Up.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2022Article
- The age differences and effect of mild cognitive impairment on perceptual-motor and executive functions.Frontiers in psychology · 2022Article
- Associations Between Self- and Informant-Reported Abilities of Instrumental Activities of Daily Living and Cognitive Functions in Older Adults With Mild Cognitive Impairment.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2021Article
- Longitudinal Assessment of Working Memory Performance in the APPswe/PSEN1dE9 Mouse Model of Alzheimer's Disease Using an Automated Figure-8-Maze.Frontiers in behavioral neuroscience · 2021Article
- Changes of Regional Neural Activity Homogeneity in Preclinical Alzheimer's Disease: Compensation and Dysfunction.Frontiers in neuroscience · 2021Article
- Quantification of cognitive impairment to characterize heterogeneity of patients at risk of developing Alzheimer's disease dementia.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Distinctive Alterations of Functional Connectivity Strength between Vascular and Amnestic Mild Cognitive Impairment.Neural plasticity · 2021Article
- Cerebral Arterial Pulsatility and Global White Matter Microstructure Impact Spatial Working Memory in Older Adults With and Without Cardiovascular Risk Factors.Frontiers in aging neuroscience · 2020Article
- Playing Mahjong for 12 Weeks Improved Executive Function in Elderly People With Mild Cognitive Impairment: A Study of Implications for TBI-Induced Cognitive Deficits.Frontiers in neurology · 2020Article
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5 authors.
Funding
Abstract
introductionThe extent of working memory (WM) and executive function (EF) impairment in mild cognitive impairment (MCI) is not well-characterized.
methodsWe compared 48 patients with MCI, 124 noncognitively impaired elderly healthy controls, and 57 patients with Alzheimer's disease (AD) on multiple WM/EF measures, frontal lobe integrity indexes, and functioning.
resultsPatients with MCI demonstrated worse performance on nearly all WM/EF tests. This profile of impairment was refined in a factor analysis that identified three primary WM/EF constructs: WM storage; speed and controlled visual search; and manipulation of information and problem solving. EF impairments were associated with reductions in prefrontal cortical thickness. WM/EF accounted for over 50% of the variance in functional competence. DISCUSSION: In MCI, WM/EF impairments are far from rare, based on specific compromises to frontal cortex circuitry, and are associated with loss of everyday functioning. WM/EF impairments, even at this potentially prodromal stage of AD, have clinically deleterious consequences.
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