Evidence map›Paper›PMID 30911581›Full record

ArticleAnnals of clinical and translational neurology2019

Quantitative vibratory sensation measurement is related to sensory cortical thickness in MS.

Nora E Fritz, Ani Eloyan, Jeffrey Glaister, Blake E Dewey, Omar Al-Louzi, M Gabriela Costello, Min Chen, Jerry L Prince, Peter A Calabresi, Kathleen M Zackowski

Abstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Cerebellar Contributions to Motor and Cognitive Control in Multiple SclerosisArchives of physical medicine and rehabilitation · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nora E FritzCenter for Movement Studies Kennedy Krieger Institute Baltimore Maryland.
Ani EloyanDepartment of Biostatistics Brown University Providence Rhode Island.
Jeffrey GlaisterDepartment of Electrical and Computer Engineering Johns Hopkins University Baltimore Maryland.
Blake E DeweyDepartment of Electrical and Computer Engineering Johns Hopkins University Baltimore Maryland.
Omar Al-LouziDepartment of Neurology Massachusetts General Hospital Brigham and Women's Hospital Harvard Medical School Boston Massachusetts.
M Gabriela CostelloCenter for Movement Studies Kennedy Krieger Institute Baltimore Maryland.
Min ChenDepartment of Electrical and Computer Engineering Johns Hopkins University Baltimore Maryland.
Jerry L PrinceDepartment of Electrical and Computer Engineering Johns Hopkins University Baltimore Maryland.
Peter A CalabresiDepartment of Neurology Johns Hopkins School of Medicine Baltimore Maryland.
Kathleen M ZackowskiCenter for Movement Studies Kennedy Krieger Institute Baltimore Maryland.

Funding

Imaging Neurodegeneration in Multiple SclerosisR01NS082347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PETER A CALABRESI, Shiv Saidha · 2013 to 2026
$7.0M
MECHANISMS OF LOCOMOTOR RECOVERY IN MULTIPLE SCLEROSISK01HD049476 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI ZACKOWSKI, KATHLEEN M. · 2006 to 2010
$499k
NICHD NIH HHS K01 HD049476NINDS NIH HHS R01 NS082347
6 · The paper itself

Abstract

Objective: Vibratory sensation is a quantifiable measure of physical dysfunction and is often related to spinal cord pathology; however, its association with relevant brain areas has not been fully explored. Our objective was to establish a cortical structural substrate for vibration sensation. Methods: Eighty-four individuals with multiple sclerosis (MS) ( Results: After controlling for age, sex, and disability level, vibratory sensation thresholds were significantly related to cortical thickness of the anterior cingulate ( Conclusions: The data show significant independent relationships between quantitative vibratory sensation and measures of primary and secondary sensory cortices. Quantitative clinical measurement of vibratory sensation reflects pathological changes in spatially distinct brain areas and may supplement information captured by brain atrophy measures. Without overt relapses, monitoring decline in progressive forms of MS has proved challenging; quantitative clinical assessment may provide a tool to examine pathological decline in this cohort. These data suggest that quantitative clinical assessment may be a reliable way to examine pathological decline and have broader relevance to progressive forms of MS.

Indexed as

AdultAgedAged, 80 and overCerebral CortexFemaleGyrus CinguliHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisParietal LobePrefrontal CortexSensationSensory ThresholdsSomatosensory Cortex

Identifiers

PMID30911581
PMCPMC6414478

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.