Evidence map›Paper›PMID 30911552›Full record

ArticleJournal of diabetes research2019

The Level of Serum Albumin Is Associated with Renal Prognosis in Patients with Diabetic Nephropathy.

Junlin Zhang, Rui Zhang, Yiting Wang, Hanyu Li, Qianqian Han, Yucheng Wu, Tingli Wang, Fang Liu

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of diabetes research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05691985 (Fibrinogen to Albumin Ratio), which is not on this map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05691985 unknown statusnot on this mapstarted 2024, after this paper: background citation

Fibrinogen to Albumin Ratio (FAR) as a Risk Factor for Type 2 Diabetic Nephropathy(DN)

Typeobservational_patient_registrySponsorAssiut UniversityRan2024 to 2025Enrolled50ConditionsCKD, Type 2 Diabetes
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.

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  13. Concentrated Polymer Brush-Modified Magnetic Particles for a Diagnostic Immunoassay.Langmuir : the ACS journal of surfaces and colloids · 2025
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Junlin ZhangDivision of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China.
Rui ZhangDivision of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China.
Yiting WangDivision of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China.
Hanyu LiDivision of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China.
Qianqian HanDivision of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China.
Yucheng WuDivision of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China.
Tingli WangDivision of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China.
Fang LiuDivision of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China.ORCID 0000-0003-1121-3004
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAlthough hypoalbuminemia is frequently found in most patients with diabetic nephropathy (DN), its relationship to the severity and progression of DN remains largely unknown. Our aim was to investigate the association between the serum albumin levels and clinicopathological features and renal outcomes in patients with type 2 diabetes mellitus (T2DM) and biopsy-proven DN. MATERIALS AND

methodsA total of 188 patients with T2DM and biopsy-proven DN followed up for at least one year were enrolled. The patients were divided into four groups based on the albumin levels: normal group: ≥35 g/L (

resultsAmong the cases, the serum albumin level had a significant correlation with proteinuria, renal function, and glomerular lesions. A multivariate Cox regression analysis indicated that the severity of hypoalbuminemia remained significantly associated with an adverse renal outcome, independent of clinical and histopathological features. In reference to the normal group, the risk of progression to ESRD increased such that the hazard ratio (HR) for the mild group was 2.09 (95% CI, 0.67-6.56,

conclusionsThese findings suggested that hypoalbuminemia was associated with a poorer renal prognosis in patients with T2DM and DN.

Indexed as

AdultDiabetes Mellitus, Type 2Diabetic NephropathiesDisease ProgressionFemaleHumansKidneyKidney Failure, ChronicKidney Function TestsMaleMiddle AgedPrognosisRisk FactorsSerum AlbuminSerum Albumin

Identifiers

PMID30911552
PMCPMC6398001
OpenAlexW2912447088

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.