Evidence map›Paper›PMID 30911415›Full record

ArticleNPJ vaccines2019

A prophylactic α-Gal-based glycovaccine effectively protects against murine acute Chagas disease.

Susana Portillo, Brenda G Zepeda, Eva Iniguez, Janet J Olivas, Nasim H Karimi, Otacilio C Moreira, Alexandre F Marques, Katja Michael, Rosa A Maldonado, Igor C Almeida

Open access · goldAbstract read
In one paragraph

Article in NPJ vaccines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 58 citations in OpenAlex.

  1. Vaccines against chronicExpert review of vaccines · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Is Zebrafish a Good Model for the Alpha-Gal Syndrome?FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  8. The time has come for a vaccine against Chagas disease.Lancet regional health. Americas · 2025
    Review
  9. Article
  10. An Update on Vaccines AgainstPathogens (Basel, Switzerland) · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Susana Portillo *1Department of Biological Sciences, Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX USA.
Brenda G Zepeda *1Department of Biological Sciences, Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX USA.
Eva Iniguez *1Department of Biological Sciences, Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX USA.
Janet J Olivas1Department of Biological Sciences, Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX USA.
Nasim H Karimi1Department of Biological Sciences, Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX USA.
Otacilio C Moreira2Laboratório de Biologia Molecular e Doenças Endêmicas, Fundação Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, Rio de Janeiro Brazil.
Alexandre F Marques1Department of Biological Sciences, Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX USA.
Katja Michael4Department of Chemistry and Biochemistry, Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX USA.
Rosa A Maldonado1Department of Biological Sciences, Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX USA.
Igor C Almeida1Department of Biological Sciences, Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX USA.ORCID 0000-0002-2443-8213
The University of Texas at El Paso · USFundação Oswaldo Cruz · BRUniversidade Federal de Minas Gerais · BR

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
TOXICOLOGY PROJECTG12RR008124 · NCRR · UNIVERSITY OF TEXAS EL PASO · PI AGUILERA, RENATO J · 1992 to 2011
$20.8M
TCCG12MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI KIRKEN, ROBERT A. · 2012 to 2018
$19.4M
RISE Scholars Program at UTEPR25GM069621 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI AGUILERA, RENATO J · 2004 to 2021
$11.2M
MARC U*STAR Program at the University of California, Los AngelesT34GM008563 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCEVOY, MEGAN M, POE, GINA R · 1996 to 2023
$9.7M
Synthetic neoglycopeptides as Chagas disease vaccineR21AI115451 · NIAID · UNIVERSITY OF TEXAS EL PASO · PI ALMEIDA, IGOR C · 2015 to 2016
$423k
NCI NIH HHS P30 CA016672NCRR NIH HHS G12 RR008124NIAID NIH HHS R21 AI115451NIGMS NIH HHS R25 GM069621NIGMS NIH HHS T34 GM008563NIMHD NIH HHS G12 MD007592
6 · The paper itself

Abstract

Chagas disease (ChD), caused by the hemoflagellate parasite

Identifiers

PMID30911415
PMCPMC6430786
OpenAlexW2922971744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.