Evidence map›Paper›PMID 30911407›Full record

ArticleCell discovery2019

Generation and characterization of a novel knockin minipig model of Hutchinson-Gilford progeria syndrome.

Beatriz Dorado, Gro Grunnet Pløen, Ana Barettino, Alvaro Macías, Pilar Gonzalo, María Jesús Andrés-Manzano, Cristina González-Gómez, Carlos Galán-Arriola, José Manuel Alfonso, Manuel Lobo and 11 more

Open access · goldAbstract read
In one paragraph

Article in Cell discovery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
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  6. Proteostasis as a Sentry for Sperm Quality and Male Fertility.Advances in experimental medicine and biology · 2025
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  14. Advances in pig models of human diseases.Animal models and experimental medicine · 2022
    Review
  15. Article
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  19. Acute kidney injury and aging.Pediatric nephrology (Berlin, Germany) · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 2 countries.

Beatriz Dorado1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Gro Grunnet Pløen3Department of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.
Ana Barettino1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Alvaro Macías1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Pilar Gonzalo1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
María Jesús Andrés-Manzano1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Cristina González-Gómez1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Carlos Galán-Arriola1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
José Manuel Alfonso1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Manuel Lobo1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Gonzalo J López-Martín1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Antonio Molina1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Raúl Sánchez-Sánchez5Laboratory of Physiology and Biotechnology of Reproduction in Swine, INIA (Spanish National Institute for Agricultural and Food Research and Technology), Madrid, Spain.
Joaquín Gadea6Department of Physiology, University of Murcia and IMIB-Arrixaca, 30100 Murcia, Spain.
Javier Sánchez-GonzálezPhilips HealthCare Iberia, 28050 Madrid, Spain.
Ying Liu8Department of Animal Science, Aarhus University, 8830 Tjele, Denmark.
Henrik Callesen8Department of Animal Science, Aarhus University, 8830 Tjele, Denmark.
David Filgueiras-Rama1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Borja Ibáñez1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Charlotte Brandt Sørensen *3Department of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.
Vicente Andrés *1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Spanish National Centre for Cardiovascular Research · ESAarhus University · DKAarhus University Hospital · DKCentro de Investigación en Red en Enfermedades Cardiovasculares · ESIberia (Spain) · ESInstituto Nacional de Investigación y Tecnología Agraria y Alimentaria · ESUniversidad de Murcia · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder for which no cure exists. The disease is characterized by premature aging and inevitable death in adolescence due to cardiovascular complications. Most HGPS patients carry a heterozygous de novo

Identifiers

PMID30911407
PMCPMC6423020
OpenAlexW2920970965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.