ArticleMultidisciplinary respiratory medicine2019
Bronchoalveolar lavage cell profiles and proteins concentrations can be used to phenotype extrinsic allergic alveolitis patients.
Article in Multidisciplinary respiratory medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases.Life (Basel, Switzerland) · 2023Article
- Factors Predictive for Immunomodulatory Therapy Response and Survival in Patients with Hypersensitivity Pneumonitis-Retrospective Cohort Analysis.Diagnostics (Basel, Switzerland) · 2022Article
- Understanding the pathogenesis of occupational coal and silica dust-associated lung disease.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- The Connection Between Selected Caspases Levels in Bronchoalveolar Lavage Fluid and Severity After Brain Injury.Frontiers in neurology · 2022Article
- Resident Fibroblast MKL1 Is Sufficient to Drive Pro-fibrogenic Response in Mice.Frontiers in cell and developmental biology · 2021Article
- Prognostic factors in chronic hypersensitivity pneumonitis.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- An unusual but unmissable link between summer-type hypersensitivity pneumonitis and asthma in an old house.Respiratory medicine case reports · 2020Article
- Associations between arterial oxygenation and oxidative stress markers in serum and bronchoalveolar lavage fluid of patients with severe brain injury.Frontiers in neurologyArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtrinsic allergic alveolitis (EAA) patients form heterogenous group with different clinical manifestation and different prognosis. We aimed to determine how to phenotype distinct EAA subgroups. Predictive role of the bronchoalveolar lavage fluid (BALF) IL-4Rα concentration at the time of diagnosis with regard to the clinical behavior in EAA patients was studied.
methodsConcentrations of MMP-7, IL-4Rα, TNF-α, and PAR-2 were measured in the BALF od 71 EAA patients at the time of diagnosis. Lung functions and outcome data were assessed at 12 months after the diagnosis. Correlations between the BALF protein concentration, cell profile, lung functions and patient outcome were determined.
resultsWe found positive correlations between BALF IL-4Rα concentration and BALF eosinophils (
conclusionsSpecific subgroup of EAA patients with more severe functional impact, distinct BALF cell profile and higher IL-4Rα BALF concentration can be differentiated. Correlations between the BALF concentrations of PAR-2, MMP-7 and TNF-α with clinical parameters may reflect the role of inflammation in the pathogenesis of EAA.
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