ArticleJournal of animal science and biotechnology2019
Genome-wide identification of RNA editing in seven porcine tissues by matched DNA and RNA high-throughput sequencing.
Article in Journal of animal science and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- A dynamic RNA editing landscape in porcine spleen highlights a post-transcriptional mechanism for immune maturation.Molecular genetics and genomics : MGG · 2026Article
- Construction and analysis of a developmental RNA editome in adipose tissue of Ningxiang pigs.BMC genomics · 2025Article
- Porcine myogenesis in cloned wildtype and MYF5/MYOD/MYF6-null porcine embryo.Communications biology · 2025Article
- An Integrated Database for Exploring Alternative Promoters in Animals.Scientific data · 2025Article
- Short Communication: The imprinted and paternally expressed MIMT1 lncRNA ortholog in pigs.Journal of animal science · 2025Article
- A comprehensive atlas of pig RNA editome across 23 tissues reveals RNA editing affecting interaction mRNA-miRNAs.G3 (Bethesda, Md.) · 2024Article
- ADAR1 Promotes Myogenic Proliferation and Differentiation of Goat Skeletal Muscle Satellite Cells.Cells · 2024Article
- Role of ADAR1 on Proliferation and Differentiation in Porcine Preadipocytes.Animals : an open access journal from MDPI · 2024Article
- Characterization of A-to-I Editing in Pigs under a Long-Term High-Energy Diet.International journal of molecular sciences · 2023Article
- The Profiles and Functions of RNA Editing Sites Associated with High-Altitude Adaptation in Goats.International journal of molecular sciences · 2023Article
- The AIRN lncRNA is imprinted and paternally expressed in pigs.Journal of animal science · 2023Article
- Granulosa Cell Specific Loss of Adar in Mice Delays Ovulation, Oocyte Maturation and Leads to Infertility.International journal of molecular sciences · 2022Article
- Landscape of adenosine-to-inosine RNA recoding across human tissues.Nature communications · 2022Article
- Loss of Monoallelic Expression ofFrontiers in genetics · 2022Article
- Landscape of tissue-specific RNA Editome provides insight into co-regulated and altered gene expression in pigs (RNA biology · 2021Article
- Genomic Imprinting at the PorcineGenes · 2021Article
- Genome-Wide Identification of RNA Editing Sites Affecting Intramuscular Fat in Pigs.Animals : an open access journal from MDPI · 2020Article
- Systematic analyses reveal RNA editing events involved in skeletal muscle development of goat (Capra hircus).Functional & integrative genomics · 2020Article
- Developmental stage-specific A-to-I editing pattern in the postnatal pineal gland of pigs (Journal of animal science and biotechnology · 2020Article
- Sex-Dependent RNA Editing andFrontiers in cell and developmental biology · 2020Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRNA editing is a co/posttranscriptional modification mechanism that increases the diversity of transcripts, with potential functional consequences. The advent of next-generation sequencing technologies has enabled the identification of RNA edits at unprecedented throughput and resolution. However, our knowledge of RNA editing in swine is still limited.
resultsHere, we utilized RES-Scanner to identify RNA editing sites in the brain, subcutaneous fat, heart, liver, muscle, lung and ovary in three 180-day-old Large White gilts based on matched strand-specific RNA sequencing and whole-genome resequencing datasets. In total, we identified 74863 editing sites, and 92.1% of these sites caused adenosine-to-guanosine (A-to-G) conversion. Most A-to-G sites were located in noncoding regions and generally had low editing levels. In total, 151 A-to-G sites were detected in coding regions (CDS), including 94 sites that could lead to nonsynonymous amino acid changes. We provide further evidence supporting a previous observation that pig transcriptomes are highly editable at PRE-1 elements. The number of A-to-G editing sites ranged from 4155 (muscle) to 25001 (brain) across the seven tissues. The expression levels of the ADAR enzymes could explain some but not all of this variation across tissues. The functional analysis of the genes with tissue-specific editing sites in each tissue revealed that RNA editing might play important roles in tissue function. Specifically, more pathways showed significant enrichment in the fat and liver than in other tissues, while no pathway was enriched in the muscle.
conclusionsThis study identified a total of 74863 nonredundant RNA editing sites in seven tissues and revealed the potential importance of RNA editing in tissue function. Our findings largely extend the porcine editome and enhance our understanding of RNA editing in swine.
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