Evidence map›Paper›PMID 30911357›Full record

ArticleInternational journal of molecular epidemiology and genetics2019

TMPRSS6 rs855791 polymorphism and susceptibility to iron deficiency anaemia in non-dialysis chronic kidney disease patients in South Africa.

Aishatu Muhammad Nalado, Caroline Dickens, Therese Dix-Peek, Johnny N Mahlangu, Gbenga Olorunfemi, Graham Paget, Raquel Duarte, Saraladevi Naicker

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of molecular epidemiology and genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Common Variants in theCurrent developments in nutrition · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Aishatu Muhammad NaladoDepartment of Internal Medicine, School of Clinical Medicine, Faculty of Health Science, University of The Witwatersrand Johannesburg, South Africa.
Caroline DickensDepartment of Internal Medicine, School of Clinical Medicine, Faculty of Health Science, University of The Witwatersrand Johannesburg, South Africa.
Therese Dix-PeekDepartment of Internal Medicine, School of Clinical Medicine, Faculty of Health Science, University of The Witwatersrand Johannesburg, South Africa.
Johnny N MahlanguSchool of Pathology, Faculty of Health Sciences, University of The Witwatersrand Johannesburg, South Africa.
Gbenga OlorunfemiDivision of Epidemiology and Biostatistics, School of Public Health, University of The Witwatersrand Johannesburg, South Africa.
Graham PagetDepartment of Internal Medicine, School of Clinical Medicine, Faculty of Health Science, University of The Witwatersrand Johannesburg, South Africa.
Raquel DuarteDepartment of Internal Medicine, School of Clinical Medicine, Faculty of Health Science, University of The Witwatersrand Johannesburg, South Africa.
Saraladevi NaickerDepartment of Internal Medicine, School of Clinical Medicine, Faculty of Health Science, University of The Witwatersrand Johannesburg, South Africa.
University of the Witwatersrand · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn genome-wide studies, there is a strong association between the TMPRSS6 allele A736V (rs855791) and significantly lower levels of serum iron, transferrin saturation, haemoglobin, and mean corpuscular volumes. The influence of this genetic variant on susceptibility to iron deficiency anaemia (IDA) in chronic kidney disease (CKD) patients is unknown.

methodsIn this cross-sectional study, we measured the full blood count and TMPRSS6 T>C polymorphism in black adult participants (n=260) with CKD and healthy controls (n=146) at the Charlotte Maxeke Johannesburg Academic Hospital, South Africa.

resultsThe overall prevalence of anaemia in the CKD and control population was 46.9% and 19.6% respectively. Twenty-six per cent of CKD participants were iron deficient. The prevalence of rs855791 C homozygosity was similar among iron deficient and non-iron deficient anaemia groups (86.1% vs 84.2%, P=0.723). When the analysis was confined to subjects with or without functional iron deficiency anaemia, C homozygote (88.3% vs 84.4%, P=0.425) was similar for both groups.

conclusionsOur study suggests that homozygosity for TMPRSS6 rs855791 C genotype does not influence IDA in non-dialysis CKD patients in our population.

Indexed as

CKDIron deficiency anaemiars855791TMPRSS6

Identifiers

PMID30911357
PMCPMC6420716
OpenAlexW2999380290

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.