Evidence map›Paper›PMID 30911344›Full record

ArticleOxidative medicine and cellular longevity2019

The Protective Role of Adiponectin for Lipoproteins in End-Stage Renal Disease Patients: Relationship with Diabetes and Body Mass Index.

Susana Coimbra, Flávio Reis, Sara Nunes, Sofia Viana, Maria João Valente, Susana Rocha, Cristina Catarino, Petronila Rocha-Pereira, Elsa Bronze-da-Rocha, Maria Sameiro-Faria and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Susana CoimbraUCIBIO/REQUIMTE, Porto, Portugal.ORCID 0000-0001-8411-8038
Flávio ReisInstitute of Pharmacology & Experimental Therapeutics, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, CNC.IBILI Consortium & CIBB Consortium, University of Coimbra, Coimbra, Portugal.ORCID 0000-0003-3401-9554
Sara NunesInstitute of Pharmacology & Experimental Therapeutics, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, CNC.IBILI Consortium & CIBB Consortium, University of Coimbra, Coimbra, Portugal.
Sofia VianaInstitute of Pharmacology & Experimental Therapeutics, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, CNC.IBILI Consortium & CIBB Consortium, University of Coimbra, Coimbra, Portugal.ORCID 0000-0002-1316-1319
Maria João ValenteUCIBIO/REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.ORCID 0000-0001-6162-2426
Susana RochaUCIBIO/REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Cristina CatarinoUCIBIO/REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Petronila Rocha-PereiraUCIBIO/REQUIMTE, Porto, Portugal.
Elsa Bronze-da-RochaUCIBIO/REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.ORCID 0000-0002-3571-2513
Maria Sameiro-FariaUCIBIO/REQUIMTE, Porto, Portugal.ORCID 0000-0002-8061-9289
José Gerardo OliveiraHemodialysis Clinic of Porto (CHP), Porto, Portugal.
José MadureiraNefroServe, Hemodialysis Clinic of Barcelos, Barcelos, Portugal.
João Carlos FernandesNefroServe Hemodialysis Clinic of Viana do Castelo, Viana do Castelo, Portugal.
Vasco MirandaHemodialysis Clinic of Gondomar, Gondomar, Portugal.
Luís BeloUCIBIO/REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.ORCID 0000-0002-3941-6850
Alice Santos-SilvaUCIBIO/REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.ORCID 0000-0002-2565-3169
Universidade do Porto · PTUniversity of Coimbra · PTCooperativa de Ensino Superior Politécnico e Universitário · PTPolytechnic Institute of Coimbra · PTPolytechnic Institute of Viana do Castelo · PTRede de Química e Tecnologia · PTUniversity of Beira Interior · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease (CVD) events are the main causes of death in end-stage renal disease (ESRD) patients on dialysis. The number and severity of CVD events remain inappropriate and difficult to explain by considering only the classic CVD risk factors. Our aim was to clarify the changes and the relationship of lipoprotein subfractions with other CVD risk factors, namely, body mass index (BMI) and adipokines, inflammation and low-density lipoprotein (LDL) oxidation, and the burden of the most prevalent comorbidities, diabetes mellitus (DM) and hypertension (HT). We studied 194 ESRD patients on dialysis and 22 controls; lipid profile, including lipoprotein subpopulations and oxidized LDL (oxLDL), C-reactive protein (CRP), adiponectin, leptin, and paraoxonase 1 activity were evaluated. Compared to controls, patients presented significantly lower levels of cholesterol, high-density lipoprotein cholesterol (HDLc), LDLc, oxLDL, and intermediate and small HDL and higher triglycerides, CRP, adiponectin, large HDL, very-low-density lipoprotein (VLDL), and intermediate-density lipoprotein- (IDL) B. Adiponectin levels correlated positively with large HDL and negatively with intermediate and small HDL, oxLDL/LDLc, and BMI; patients with DM (

Indexed as

Body Mass IndexAdiponectinAryldialkylphosphataseC-Reactive ProteinDiabetes MellitusFemaleHumansKidney Failure, ChronicLipoproteinsMaleMiddle AgedProtective AgentsAdiponectinAryldialkylphosphataseC-Reactive ProteinLipoproteinsPON1 protein, humanProtective Agents

Identifiers

PMID30911344
PMCPMC6397972
OpenAlexW2912851006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.