Evidence map›Paper›PMID 30911305›Full record

ArticleJournal of contemporary brachytherapy2019

Subdermal injection of hyaluronic acid to decrease skin toxicity from radiation delivered with low-dose-rate brachytherapy for cancer patients.

Yuan Yuan, Zhang Ying, Dai Jianjian, Lin Qi, Xu Ruicai, Geng Baocheng, Han Mingyong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of contemporary brachytherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Success ofOncoTargets and therapy · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yuan YuanCancer Therapy and Research Center, Shandong Provincial Hospital affiliated to Shandong University, Shandong University, Jinan, P. R China.
Zhang YingCancer Therapy and Research Center, Shandong Provincial Hospital affiliated to Shandong University, Shandong University, Jinan, P. R China.
Dai JianjianCancer Therapy and Research Center, Shandong Provincial Hospital affiliated to Shandong University, Shandong University, Jinan, P. R China.
Lin QiCancer Therapy and Research Center, Shandong Provincial Hospital affiliated to Shandong University, Shandong University, Jinan, P. R China.
Xu RuicaiCancer Therapy and Research Center, Shandong Provincial Hospital affiliated to Shandong University, Shandong University, Jinan, P. R China.
Geng BaochengMedical Imaging Department, Shandong Provincial Hospital affiliated to Shandong University, Shandong University, Jinan, P. R China.
Han MingyongCancer Therapy and Research Center, Shandong Provincial Hospital affiliated to Shandong University, Shandong University, Jinan, P. R China.
Shandong Provincial Hospital · CNShandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo study the feasibility of hyaluronic acid (HA) injection to increase the distance between skin and radioactive sources, and dose reduction of skin during low-dose-rate (LDR) brachytherapy.Material and methods: A total of 11 patients with subdermal malignant tumors were enrolled in this study. HA was injected after I-125 seed implantation, and dosimetric parameters were calculated by a brachytherapy treatment planning system (BTPS). The distance of the new space between radioactive sources and skin was measured on computed tomography (CT) and magnetic resonance imaging (MRI). Clinical signs were observed and followed up for every patient.

resultsAfter HA injection, the average of newly generated maximum distance was 1.0 cm along the entire length of the tumor. The D

conclusionsOur study results showed that an additional 1.0 cm distance between the radioactive source and skin could be induced by HA injection in patients with subdermal tumor, and this distance could significantly decrease the skin dose in LDR brachytherapy. In addition, no obvious toxicity and side effects were produced by HA injection. Therefore, hyaluronic acid injection is a safe and effective technique.

Indexed as

hyaluronic acidlow-dose-rate brachytherapysubdermal malignant tumor

Identifiers

PMID30911305
PMCPMC6431100
OpenAlexW2923569984

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.