Evidence map›Paper›PMID 30911298›Full record

ArticleStem cells international2019

Obesity-Induced Methylation of Osteopontin Contributes to Adipogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells.

Min Tang, Rui Chen, Hao Wang, Guowei Sun, Fan Yin, Beibei Liang, Yang Yang, Gaowa Sharen, Huafeng Wei, Xuyu Zhou and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Min TangShanghai Key Laboratory for Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.ORCID 0000-0001-8045-5782
Rui ChenAngecon Biotechnology Limited, Shanghai 201318, China.
Hao WangAir Force Hospital, Northern Theater Command, PLA, China.ORCID 0000-0002-8626-7480
Guowei SunThe Arctic Temple Clinic, Beijing Fourth Service Center, 8 Garden East Road, Beijing 100191, China.
Fan YinCancer Center Key Lab, PLA General Hospital, Beijing 100853, China.
Beibei LiangShanghai Key Laboratory for Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
Yang YangCentral Research Institute of Shanghai Pharmaceutical (Group) Co., Ltd., Shanghai 201203, China.
Gaowa SharenCancer Center Key Lab, PLA General Hospital, Beijing 100853, China.
Huafeng WeiCancer Center Key Lab, PLA General Hospital, Beijing 100853, China.
Xuyu ZhouChanghai Hospital, The Second Military Medical University, Shanghai 200438, China.ORCID 0000-0002-5259-7393
Gang HuangShanghai Key Laboratory for Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.ORCID 0000-0003-3936-9123
Jian ZhaoShanghai Key Laboratory for Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.ORCID 0000-0001-8131-8886
Chinese PLA General Hospital · CNShanghai University of Medicine and Health Sciences · CNSecond Military Medical University · CNShanghai Institute of Pharmaceutical Industry · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a major risk factor for many chronic diseases, including diabetes, fatty livers, and cancer. Expansion of the adipose mass has been shown to be related to adipogenic differentiation of adipose-derived mesenchymal stem cells (ASCs). However, the underlying mechanism of this effect has yet to be elucidated. We found that osteopontin (OPN) is downregulated in ASCs and adipose tissues of obese mice and overweight human beings because of methylation on its promoter, indicating that OPN may affect the development of obesity. Silencing of OPN in wild-type ASCs promotes adipogenic differentiation, while reexpression of OPN reduced adipogenic differentiation in OPN

Identifiers

PMID30911298
PMCPMC6398038
OpenAlexW2913249572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.