ArticleNature neuroscience2019
Oxytocin modulates social value representations in the amygdala.
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Linking Central Gene Expression Patterns and Mental States Using Transcriptomics and Large-Scale Meta-Analysis of fMRI Data: A Tutorial and Example Using the Oxytocin Signaling Pathway.Methods in molecular biology (Clifton, N.J.) · 2022Pooled it
- Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top-Down Middle Cingulate Amygdala Regulation and Brain-Wide Fear Representations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Trial
- Intranasal oxytocin decreases self-oriented learning.Psychopharmacology · 2021Trial
- Trial
- Oxytocin facilitates valence-dependent valuation of social evaluation of the self.Communications biology · 2020Trial
- Oxytocin modulates the neurocomputational mechanisms engaged in learning rank relationships in social networks.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Self-allocation bias in performance-based cooperative decisions is driven by self-interest rather than distorted performance encoding.PLoS biology · 2026Article
- Circuit logic of oxytocin and vasopressin complementary actions.Frontiers in neuroscience · 2026Review
- Exploring individual differences in the impact of cognitive constraints on prosocial decision-making via intrinsic brain connectivity.Brain imaging and behavior · 2025Article
- Article
- Oxytocin in the Amygdala Sustains Prosocial Behavior via State-Dependent Amygdala-Prefrontal Modulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A cell-type-specific epigenetic mechanism encodes social investigatory behavior via Lrhcn1 and Hcn1.Science advances · 2025Article
- Effects of systemic oxytocin receptor activation and blockade on risky decision making in female and male rats.Behavioral neuroscience · 2025Article
- Relative social status alters the synchrony of attribute integration in altruistic decisions.iScience · 2025Article
- Simultaneous intracranial recordings of interacting brains reveal neurocognitive dynamics of human cooperation.Nature neuroscience · 2025Article
- Neurocognitive dynamics of human cooperation unveiled by intracranial recordings.Nature neuroscience · 2025Article
- Social observation differentially affects prosocial learning of selfish and prosocial people.Frontiers in psychology · 2025Article
- The missing hallmark of health: psychosocial adaptation.Cell stress · 2024Article
- Oxytocin enhances the triangular association among behavior, resting-state, and task-state functional connectivity.Human brain mapping · 2023Article
- Article
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9 authors at 4 institutions in 3 countries.
Funding
Abstract
Humans exhibit considerable variation in how they value their own interest relative to the interests of others. Deciphering the neural codes representing potential rewards for self and others is crucial for understanding social decision-making. Here we integrate computational modeling with functional magnetic resonance imaging to investigate the neural representation of social value and the modulation by oxytocin, a nine-amino acid neuropeptide, in participants evaluating monetary allocations to self and other (self-other allocations). We found that an individual's preferred self-other allocation serves as a reference point for computing the value of potential self-other allocations. In more prosocial participants, amygdala activity encoded a social-value-distance signal; that is, the value dissimilarity between potential and preferred allocations. Intranasal oxytocin administration amplified this amygdala representation and increased prosocial behavior in more individualistic participants but not in more prosocial ones. Our results reveal a neurocomputational mechanism underlying social-value representations and suggest that oxytocin may promote prosociality by modulating social-value representations in the amygdala.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.