ArticleNature protocols2019
Nanoscale chemical imaging using tip-enhanced Raman spectroscopy.
Article in Nature protocols, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 119 citations in OpenAlex.
- Development of scanning ion-conductance microscopy based tip-enhanced Raman spectroscopy in liquid environments.Nanotechnology · 2026Review
- Article
- Bioanalysis Using Surface-Enhanced Raman Spectroscopy: From the Perspective of Single Molecules.ACS nano · 2026Review
- Nanoscale Chemical Analysis of Heterogeneous Catalysts Using Tip-Enhanced Raman Spectroscopy.Chemical reviews · 2026Review
- A Perspective intoThe journal of physical chemistry letters · 2026Review
- Nanoscale Imaging of Biological Tissues: Techniques, Challenges and Emerging Frontiers.Nanomaterials (Basel, Switzerland) · 2025Review
- Atomic Force Microscopy for Cross-Disciplinary Materials Research.Small methods · 2025Review
- Plasmonic nanoparticle sensors: current progress, challenges, and future prospects.Nanoscale horizons · 2024Review
- Impact of Surface Enhanced Raman Spectroscopy in Catalysis.ACS nano · 2024Review
- Crystallization of molecular layers produced under confinement onto a surface.Nature communications · 2024Article
- Current Trends of Raman Spectroscopy in Clinic Settings: Opportunities and Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Galvanic-Replacement-Assisted Synthesis of Nanostructured Silver-Surface for SERS Characterization of Two-Dimensional Polymers.Sensors (Basel, Switzerland) · 2024Article
- Accessible hotspots for single-protein SERS in DNA-origami assembled gold nanorod dimers with tip-to-tip alignment.Nature communications · 2023Article
- Nanoimaging of Facet-Dependent Adsorption, Diffusion, and Reactivity of Surface Ligands on Au Nanocrystals.Nano letters · 2023Article
- Mechanistic Insights Gained by High Spatial Resolution Reactivity Mapping of Homogeneous and Heterogeneous (Electro)Catalysts.Chemical reviews · 2023Review
- Toward the Next Frontiers of Vibrational Bioimaging.Chemical & biomedical imaging · 2023Review
- Nanoscale chemical analysis of 2D molecular materials using tip-enhanced Raman spectroscopy.Nanoscale · 2023Review
- Structure sensitivity in gas sorption and conversion on metal-organic frameworks.Nature communications · 2023Article
- Probing coke formation during the methanol-to-hydrocarbon reaction on zeolite ZSM-5 catalyst at the nanoscale using tip-enhanced fluorescence microscopy.Catalysis science & technology · 2022Article
- Plasmonic phenomena in molecular junctions: principles and applications.Nature reviews. Chemistry · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Confocal and surface-enhanced Raman spectroscopy (SERS) are powerful techniques for molecular characterization; however, they suffer from the drawback of diffraction-limited spatial resolution. Tip-enhanced Raman spectroscopy (TERS) overcomes this limitation and provides chemical information at length scales in the tens of nanometers. In contrast to alternative approaches to nanoscale chemical analysis, TERS is label free, is non-destructive, and can be performed in both air and liquid environments, allowing its use in a diverse range of applications. Atomic force microscopy (AFM)-based TERS is especially versatile, as it can be applied to a broad range of samples on various substrates. Despite its advantages, widespread uptake of this technique for nanoscale chemical imaging has been inhibited by various experimental challenges, such as limited lifetime, and the low stability and yield of TERS probes. This protocol details procedures that will enable researchers to reliably perform TERS imaging using a transmission-mode AFM-TERS configuration on both biological and non-biological samples. The procedure consists of four stages: (i) preparation of plasmonically active TERS probes; (ii) alignment of the TERS system; (iii) experimental procedures for nanoscale imaging using TERS; and (iv) TERS data processing. We provide procedures and example data for a range of different sample types, including polymer thin films, self-assembled monolayers (SAMs) of organic molecules, photocatalyst surfaces, small molecules within biological cells, single-layer graphene and single-walled carbon nanotubes in both air and water. With this protocol, TERS probes can be prepared within ~23 h, and each subsequent TERS experimental procedure requires 3-5 h.
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Registered trials
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