Evidence map›Paper›PMID 30911136›Full record

ArticleNature medicine2019

Distinct phenotype of CD4

Asbjørn Christophersen, Eivind G Lund, Omri Snir, Elsa Solà, Chakravarthi Kanduri, Shiva Dahal-Koirala, Stephanie Zühlke, Øyvind Molberg, Paul J Utz, Mina Rohani-Pichavant and 5 more

Open access · greenAbstract read
In one paragraph

Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 166 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Gliadin-specific CD4Science advances · 2026
    Article
  4. Review
  5. Narcolepsy is (not) an autoimmune disease.Nature reviews. Neurology · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. T cell receptors for antigen on intraepithelial cytolytic T lymphocytes in celiac disease engage enterocyte HLA-E and HLA-B.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Review
  11. Article
  12. IFN-γ is a direct driver of crypt hyperplasia in celiac disease.The Journal of clinical investigation · 2025
    Article
  13. Detection of Gliadin-Activated CD4Journal of cellular and molecular medicine · 2025
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 4 countries.

Asbjørn ChristophersenKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
Eivind G LundKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0003-1440-1182
Omri SnirKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
Elsa SolàInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Chakravarthi KanduriKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
Shiva Dahal-KoiralaKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
Stephanie ZühlkeKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
Øyvind MolbergInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Paul J UtzInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Mina Rohani-PichavantInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Julia F SimardEpidemiology, Health Research and Policy, Stanford School of Medicine, Stanford, CA, USA.
Cornelia L DekkerDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-3871-918X
Knut E A LundinKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
Ludvig M SollidKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway. l.m.sollid@medisin.uio.no.ORCID http://orcid.org/0000-0001-8860-704X
Mark M DavisInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA. mmdavis@stanford.edu.ORCID http://orcid.org/0000-0001-6868-657X
University of Oslo · NOOslo University Hospital · NOStanford University · USHospital Clínic de Barcelona · ESHoward Hughes Medical Institute · USStanford Medicine · US

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Giant MagnetoResistive (GMR) Sensors for Measuring Influenza VaccineR01AI125197 · NIAID · STANFORD UNIVERSITY · PI UTZ, PAUL JOSEPH, WANG, SHAN X. · 2016 to 2021
$5.0M
Ultra-Fast Epigenomic Maps for Monitoring AutoimmunityU19AI110491 · NIAID · STANFORD UNIVERSITY · PI UTZ, PAUL JOSEPH · 2014 to 2018
$3.6M
NCATS NIH HHS UL1 TR001085NCATS NIH HHS UL1 TR003142NIAID NIH HHS R01 AI125197NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI110491
6 · The paper itself

Abstract

Combining HLA-DQ-gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4

Indexed as

Autoimmune DiseasesCD4-Positive T-LymphocytesCeliac DiseaseGlutensHLA-DQ AntigensHumansImmunophenotypingIntestinesLupus Erythematosus, SystemicScleroderma, SystemicT-Lymphocyte SubsetsGlutensHLA-DQ Antigens

Identifiers

PMID30911136
PMCPMC6647859
OpenAlexW2923342978

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.