Evidence map›Paper›PMID 30911081›Full record

Observational studyJournal of perinatology : official journal of the California Perinatal Association2019

Cardiac mechanics in infants with Down syndrome in the early neonatal period.

Colm R Breatnach, Neidin Bussmann, Aisling Smith, Phil Levy, Naomi McCallion, Orla Franklin, Afif El-Khuffash

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Colm R BreatnachDepartment of Neonatology, The Rotunda Hospital, Dublin, Ireland.
Neidin BussmannDepartment of Neonatology, The Rotunda Hospital, Dublin, Ireland.
Aisling SmithDepartment of Neonatology, The Rotunda Hospital, Dublin, Ireland.
Phil LevyDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.
Naomi McCallionDepartment of Neonatology, The Rotunda Hospital, Dublin, Ireland.
Orla FranklinDepartment of Cardiology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.
Afif El-KhuffashDepartment of Neonatology, The Rotunda Hospital, Dublin, Ireland. afifelkhuffash@rcsi.ie.ORCID http://orcid.org/0000-0002-2933-822X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study is to test whether myocardial performance is impaired over the first week of age in infants with Down syndrome (DS) without congenital heart disease (CHD). STUDY

designA prospective cohort study of 20 infants with DS without CHD and 17 healthy term infants comparing echocardiographic measures of left (LV) and right (RV) ventricular function and pulmonary hypertension (PH) on days 1, 2, and 5-7.

resultsIndices of PH were higher in the DS group over the study period. Infants with DS had larger RV and smaller LV dimensions. Fractional area change and RV longitudinal strain values were lower in the DS group. LV shear strain values were lower in infants with DS driven by a lack of basal rotation.

conclusionInfants with DS without CHD and echocardiographic evidence of PH during the early neonatal period demonstrate reduced RV systolic function with impaired LV rotational mechanics, reflective of the ventricular interdependence.

Indexed as

Down SyndromeEchocardiographyFemaleHeart VentriclesHumansHypertension, PulmonaryInfant, NewbornMaleProspective StudiesVentricular Function

Identifiers

PMID30911081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.