Evidence map›Paper›PMID 30911042›Full record

ArticleScientific reports2019

Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro.

Ricardo Correa, Lorena Coronado, Zuleima Caballero, Paula Faral-Tello, Carlos Robello, Carmenza Spadafora

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Synthesis of AgJournal of functional biomaterials · 2025
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  3. Cell Death ofPathogens (Basel, Switzerland) · 2024
    Article
  4. Article
  5. Review
  6. In Silico Studies of Four Compounds ofMolecules (Basel, Switzerland) · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Erythropoiesis and Malaria, a Multifaceted Interplay.International journal of molecular sciences · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Perils and Promises of Pathogenic Protozoan Extracellular Vesicles.Frontiers in cellular and infection microbiology · 2020
    Review
  18. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Ricardo CorreaCenter of Cellular and Molecular Biology of Diseases, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP). City of Knowledge, Panama City, 0843-01103, Panama.
Lorena CoronadoCenter of Cellular and Molecular Biology of Diseases, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP). City of Knowledge, Panama City, 0843-01103, Panama.
Zuleima CaballeroCenter of Cellular and Molecular Biology of Diseases, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP). City of Knowledge, Panama City, 0843-01103, Panama.
Paula Faral-TelloInstitut Pasteur, Montevideo, Uruguay.
Carlos RobelloInstitut Pasteur, Montevideo, Uruguay.ORCID http://orcid.org/0000-0001-6985-6171
Carmenza SpadaforaCenter of Cellular and Molecular Biology of Diseases, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP). City of Knowledge, Panama City, 0843-01103, Panama. cspadafora@indicasat.org.pa.ORCID http://orcid.org/0000-0002-3002-9467
Secretaría Nacional de Ciencia, Tecnología e Innovación · PAInstitut Pasteur de Montevideo · UYAcharya Nagarjuna University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Even with access to sufficient nutrients and atmosphere, Plasmodium falciparum can barely be cultured at maximum growth capacity in vitro conditions. Because of this behavior, it has been suggested that P. falciparum has self-regulatory mechanisms in response to density stress. Only recently has this process begun to be acknowledged and characteristics of a programmed cell death been assigned to the parasite at high parasitaemia in vitro cultures. In searching for death signals within the parasite community, we have found that extracellular vesicles (EVs) of P. falciparum from high parasitaemia cultures are able to induce programmed cell death processes in the population. A comparative proteomic analysis of EVs from low (EV

Indexed as

ApoptosisExtracellular VesiclesHumansL-Lactate DehydrogenasePlasmodium falciparumProtozoan ProteinsL-Lactate DehydrogenaseProtozoan Proteins

Identifiers

PMID30911042
PMCPMC6434017
OpenAlexW2923686560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.