ArticleNature communications2019
Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT.
Registry-linked trialAbstract read
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04622423 (Advanced Immune Gene and Cell Therapies for Liver Metastases), which is not on this map. Cited by 133 papers, 1 of them a synthesis that pooled it.
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0cells of the map it votes in
133citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Advanced Immune Gene and Cell Therapies for Liver Metastases
Who cites it
133 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acute Myeloid Leukemia: From Biology to Clinical Practices Through Development and Pre-Clinical Therapeutics.Frontiers in oncology · 2020Pooled it
- WT1 peptide vaccines of post-allogeneic HSCT maintenance immunotherapy for pediatric acute leukemias: a phase 2 study.Blood advances · 2026Trial
- Azacitidine-induced reconstitution of the bone marrow T cell repertoire is associated with superior survival in AML patients.Blood cancer journal · 2022Trial
- Inflammation as a central driver in AML pathogenesis and therapy resistance.Science China. Life sciences · 2026Review
- Monocyte Galectin-9 is associated with CD8⁺ T-cell dysfunction and early relapse after haploidentical hematopoietic stem cell transplantation.Biomarker research · 2026Article
- Pediatric AML CAR T cell therapy.Molecular therapy. Oncology · 2026Review
- Mechanisms of post-transplant AML relapse and therapeutic implications.Bone marrow transplantation · 2026Article
- Early high-resolution immune profiles are associated with survival, relapse and graft-versus-host-disease after allogeneic hematopoietic cell transplantation.Bone marrow transplantation · 2026Article
- Cholesterol Reprogramming in Acute Myeloid Leukemia: Integrating Tumor-Intrinsic Metabolism and Immune Crosstalk.Diseases (Basel, Switzerland) · 2026Review
- The impact of T cell exhaustion in hematopoietic stem cell transplantation.Stem cell research & therapy · 2026Review
- Single-Cell Multiomics Decoding of TCIRG1-Mediated Cuproptosis Circuitry Rewiring Immune-Metabolic Landscape in Ischemic Stroke.Translational stroke research · 2026Article
- Overcoming resistance to immune checkpoint inhibitor therapy in acute myeloid leukemia.Frontiers in oncology · 2026Review
- Beyond exhaustion: T cell fitness for next generation of immunotherapy for hematological cancer.Frontiers in immunology · 2026Review
- Mechanistic basis and therapeutic modulation of T cell fitness to enhance CAR-T cell efficacy in hematological malignancies.Frontiers in immunology · 2026Review
- Novel approaches for separating graft-versus-leukemia effects from graft-versus-host disease.Frontiers in oncology · 2026Review
- Immune monitoring for relapse of acute myeloid leukemia after allogeneic stem cell transplantation in clinical laboratories.Frontiers in immunology · 2026Review
- Gene transfer and genome editing of T cells for cancer immunotherapy: from allogeneic HSCT to TCR gene editing.Hematology. American Society of Hematology. Education Program · 2025Review
- T Cell immune reconstitution after allo-HSCT: key factors and implications.Blood science (Baltimore, Md.) · 2025Review
- Bone marrow and blood demonstrate distinct immune reconstitution patterns and correlations with relapse posttransplant.Blood advances · 2025Article
- The role of TCF-1+CD8+ exhausted progenitors and TCF-1 in graft-versus-host responses.JCI insight · 2025Article
73 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors.
Maddalena NovielloIRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation, and Infectious Diseases, Experimental Hematology Unit, via Olgettina 60, Milan, 20132, Italy.
Francesco ManfrediIRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation, and Infectious Diseases, Experimental Hematology Unit, via Olgettina 60, Milan, 20132, Italy.
Eliana RuggieroIRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation, and Infectious Diseases, Experimental Hematology Unit, via Olgettina 60, Milan, 20132, Italy.
Tommaso PeriniIRCCS San Raffaele Scientific Institute, Hematology and Hematopoietic Stem Cell Transplantation Unit, via Olgettina 60, Milan, 20132, Italy.
Giacomo OliveiraIRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation, and Infectious Diseases, Experimental Hematology Unit, via Olgettina 60, Milan, 20132, Italy.
Filippo CortesiIRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation and Infectious Diseases, Experimental Immunology Unit, via Olgettina 60, Milan, 20132, Italy.
Pantaleo De SimoneIRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation, and Infectious Diseases, Experimental Hematology Unit, via Olgettina 60, Milan, 20132, Italy.
Cristina ToffaloriIRCCS San Raffaele Scientifc Institute, Division of Immunology, Transplantation and Infectious Disease, Unit of Immunogenetics, Leukemia Genomics and Immunobiology, via Olgettina 60, Milan, 20132, Italy.
Valentina GambacortaIRCCS San Raffaele Scientifc Institute, Division of Immunology, Transplantation and Infectious Disease, Unit of Immunogenetics, Leukemia Genomics and Immunobiology, via Olgettina 60, Milan, 20132, Italy.
Raffaella GrecoIRCCS San Raffaele Scientific Institute, Hematology and Hematopoietic Stem Cell Transplantation Unit, via Olgettina 60, Milan, 20132, Italy.
Jacopo PeccatoriIRCCS San Raffaele Scientific Institute, Hematology and Hematopoietic Stem Cell Transplantation Unit, via Olgettina 60, Milan, 20132, Italy.
Monica CasucciIRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation and Infectious Diseases, Innovative Immunotherapies Unit, via Olgettina 60, Milan, 20132, Italy.
Giulia CasoratiIRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation and Infectious Diseases, Experimental Immunology Unit, via Olgettina 60, Milan, 20132, Italy.
Paolo DellabonaIRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation and Infectious Diseases, Experimental Immunology Unit, via Olgettina 60, Milan, 20132, Italy.
Masahiro OnozawaHokkaido University Faculty of Medicine, Graduate School of Medicine, Department of Hematology, 5 Chome Kita 8 Jonishi, Kita, Sapporo, 060-0808, Japan.
Takanori TeshimaHokkaido University Faculty of Medicine, Graduate School of Medicine, Department of Hematology, 5 Chome Kita 8 Jonishi, Kita, Sapporo, 060-0808, Japan.ORCID http://orcid.org/0000-0002-0941-271X
Marieke GriffioenLeiden University Medical Center (LUMC), Department of Hematology, Albinusdreef 2, Leiden, 2333, The Netherlands.
Constantijn J M HalkesLeiden University Medical Center (LUMC), Department of Hematology, Albinusdreef 2, Leiden, 2333, The Netherlands.
J H F FalkenburgLeiden University Medical Center (LUMC), Department of Hematology, Albinusdreef 2, Leiden, 2333, The Netherlands.
Friedrich StölzelDepartment of Internal Medicine I, University Hospital Carl Gustav Carus Dresden, Technical University Dresden, Fetsherstrasse 74, Dresden, 01307, Germany.
Heidi AltmannDepartment of Internal Medicine I, University Hospital Carl Gustav Carus Dresden, Technical University Dresden, Fetsherstrasse 74, Dresden, 01307, Germany.
Martin BornhäuserDepartment of Internal Medicine I, University Hospital Carl Gustav Carus Dresden, Technical University Dresden, Fetsherstrasse 74, Dresden, 01307, Germany.
Miguel WaterhouseUniversity of Freiburg Medical Center, Department of Hematology, Oncology and Stem Cell Transplantation, Hugstetterstr 55, Freiburg, 79106, Germany.
Robert ZeiserUniversity of Freiburg Medical Center, Department of Hematology, Oncology and Stem Cell Transplantation, Hugstetterstr 55, Freiburg, 79106, Germany.
Jürgen FinkeUniversity of Freiburg Medical Center, Department of Hematology, Oncology and Stem Cell Transplantation, Hugstetterstr 55, Freiburg, 79106, Germany.
Nicoletta CieriIRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation, and Infectious Diseases, Experimental Hematology Unit, via Olgettina 60, Milan, 20132, Italy.
Attilio BondanzaIRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation and Infectious Diseases, Innovative Immunotherapies Unit, via Olgettina 60, Milan, 20132, Italy.
Luca VagoIRCCS San Raffaele Scientifc Institute, Division of Immunology, Transplantation and Infectious Disease, Unit of Immunogenetics, Leukemia Genomics and Immunobiology, via Olgettina 60, Milan, 20132, Italy.
Fabio CiceriIRCCS San Raffaele Scientific Institute, Hematology and Hematopoietic Stem Cell Transplantation Unit, via Olgettina 60, Milan, 20132, Italy.
Chiara BoniniIRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation, and Infectious Diseases, Experimental Hematology Unit, via Olgettina 60, Milan, 20132, Italy. bonini.chiara@hsr.it.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major cause of death after allogeneic Hematopoietic Stem Cell Transplantation (HSCT) for acute myeloid leukemia (AML) is disease relapse. We investigated the expression of Inhibitory Receptors (IR; PD-1/CTLA-4/TIM-3/LAG-3/2B4/KLRG1/GITR) on T cells infiltrating the bone marrow (BM) of 32 AML patients relapsing (median 251 days) or maintaining complete remission (CR; median 1 year) after HSCT. A higher proportion of early-differentiated Memory Stem (T
Indexed as
Clonal AnergyGene Expression Regulation, LeukemicHematopoietic Stem Cell TransplantationAdultAntigens, CDAntineoplastic AgentsBone Marrow CellsCTLA-4 AntigenFemaleGlucocorticoid-Induced TNFR-Related ProteinHepatitis A Virus Cellular Receptor 2HumansImmunologic MemoryLeukemia, Myeloid, AcuteLymphocyte Activation Gene 3 ProteinMaleAntigens, CDAntineoplastic AgentsCD244 protein, humanCTLA-4 AntigenGlucocorticoid-Induced TNFR-Related ProteinHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2Lag3 protein, humanLymphocyte Activation Gene 3 ProteinPDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptors, KIRSignaling Lymphocytic Activation Molecule FamilyTNFRSF18 protein, human
Identifiers
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Read underepoch 390
Registered trials
NCT04622423ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.