Evidence map›Paper›PMID 30910993›Full record

ArticleAging2019

Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells.

Sadanand Fulzele, Bharati Mendhe, Andrew Khayrullin, Maribeth Johnson, Helen Kaiser, Yutao Liu, Carlos M Isales, Mark W Hamrick

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 2 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 2 syntheses or guidelines pooled it, 195 citations in OpenAlex.

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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sadanand FulzeleMedical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Bharati MendheMedical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Andrew KhayrullinMedical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Maribeth JohnsonMedical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Helen KaiserMedical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Yutao LiuMedical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Carlos M IsalesMedical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Mark W HamrickMedical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Augusta University · US

Funding

THE LEPTIN-IGF1 AXIS IN MUSCULOSKELETAL AGINGP01AG036675 · NIA · AUGUSTA UNIVERSITY · PI Meghan E. McGee-Lawrence · 2011 to 2026
$31.5M
NIA NIH HHS P01 AG036675
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are known to play important roles in cell-cell communication. Here we investigated the role of muscle-derived EVs and their microRNAs in the loss of bone stem cell populations with age. Aging in male and female C57BL6 mice was associated with a significant increase in expression of the senescence-associated microRNA miR-34a-5p (miR-34a) in skeletal muscle and in serum -derived EVs. Muscle-derived, alpha-sarcoglycan positive, EVs isolated from serum samples also showed a significant increase in miR-34a with age. EVs were isolated from conditioned medium of C2C12 mouse myoblasts and primary human myotubes after cells were treated with hydrogen peroxide to simulate oxidative stress. These EVs were shown to have elevated levels of miR-34a, and these EVs decreased viability of bone marrow mesenchymal (stromal) cells (BMSCs) and increased BMSC senescence. A lentiviral vector system was used to overexpress miR-34a in C2C12 cells, and EVs isolated from these transfected cells were observed to home to bone

Indexed as

AgingAnimalsExtracellular VesiclesFemaleHumansMaleMesenchymal Stem CellsMiceMice, Inbred C57BLMicroRNAsMuscle, SkeletalMicroRNAsMIRN34a microRNA, mouseexosomesmuscle-bone crosstalkosteoporosissarcopeniasenescence

Identifiers

PMID30910993
PMCPMC6461183
OpenAlexW2929898918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.