ArticleProceedings of the National Academy of Sciences of the United States of America2019
Internal representation of hippocampal neuronal population spans a time-distance continuum.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Distinct neural signatures of hippocampal population dynamics during locomotion-in-place.Scientific reports · 2026Article
- Neural heterogeneity enables adaptive encoding of time sequences.Communications physics · 2025Article
- Review
- Learning heterogeneous delays in a layer of spiking neurons for fast motion detection.Biological cybernetics · 2023Article
- Article
- Linking temporal coordination of hippocampal activity to memory function.Frontiers in cellular neuroscience · 2023Review
- Precise Spiking Motifs in Neurobiological and Neuromorphic Data.Brain sciences · 2022Review
- Complementary roles of differential medial entorhinal cortex inputs to the hippocampus for the formation and integration of temporal and contextual memory (Systems Neuroscience).The European journal of neuroscience · 2021Review
- Do hippocampal pyramidal cells respond to nonspatial stimuli?Physiological reviews · 2021Review
- Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Crucial role for CA2 inputs in the sequential organization of CA1 time cells supporting memory.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Theta-Nested Gamma Oscillations in Next Generation Neural Mass Models.Frontiers in computational neuroscience · 2020Article
- Article
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7 authors.
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Abstract
The hippocampus plays a critical role in episodic memory: the sequential representation of visited places and experienced events. This function is mirrored by hippocampal activity that self organizes into sequences of neuronal activation that integrate spatiotemporal information. What are the underlying mechanisms of such integration is still unknown. Single cell activity was recently shown to combine time and distance information; however, it remains unknown whether a degree of tuning between space and time can be defined at the network level. Here, combining daily calcium imaging of CA1 sequence dynamics in running head-fixed mice and network modeling, we show that CA1 network activity tends to represent a specific combination of space and time at any given moment, and that the degree of tuning can shift within a continuum from 1 day to the next. Our computational model shows that this shift in tuning can happen under the control of the external drive power. We propose that extrinsic global inputs shape the nature of spatiotemporal integration in the hippocampus at the population level depending on the task at hand, a hypothesis which may guide future experimental studies.
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