Evidence map›Paper›PMID 30910980›Full record

Trial reportProceedings of the National Academy of Sciences of the United States of America2019

A specific amino acid motif of

Jill A Hollenbach, Paul J Norman, Lisa E Creary, Vincent Damotte, Gonzalo Montero-Martin, Stacy Caillier, Kirsten M Anderson, Maneesh K Misra, Neda Nemat-Gorgani, Kazutoyo Osoegawa and 9 more

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Human leukocyte antigen in Parkinson's disease: A systematic review and meta-analysis of risk and clinical attributes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  2. Shared Epitope-PositiveNeurology(R) neuroimmunology & neuroinflammation · 2026
    Article
  3. Genetic and Proteomic Investigation of the Smoking-Parkinson's Disease Association.medRxiv : the preprint server for health sciences · 2026
    Article
  4. Article
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  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. An immunogenetic basis for lung cancer risk.Science (New York, N.Y.) · 2024
    Article
  17. Clearing the Smoke: What Protects Smokers from Parkinson's Disease?Movement disorders : official journal of the Movement Disorder Society · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 1 country.

Jill A HollenbachUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA 94158; Jill.Hollenbach@ucsf.edu.ORCID 0000-0001-6572-7962
Paul J NormanDivision of Personalized Medicine, Department of Microbiology and Immunology, University of Colorado Denver, Aurora, CO 80045.
Lisa E CrearyDepartment of Pathology, Stanford University, Palo Alto, CA 94304.
Vincent DamotteUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA 94158.ORCID 0000-0002-7321-8575
Gonzalo Montero-MartinDepartment of Pathology, Stanford University, Palo Alto, CA 94304.
Stacy CaillierUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA 94158.
Kirsten M AndersonUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA 94158.
Maneesh K MisraUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA 94158.ORCID 0000-0002-3757-3326
Neda Nemat-GorganiDepartment of Structural Biology, Stanford University, Stanford, CA 94305.
Kazutoyo OsoegawaHistocompatibility, Immunogenetics & Disease Profiling Laboratory, Stanford Blood Center, Palo Alto, CA 94304.
Adam SantanielloUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA 94158.
Adam RenschenUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA 94158.
Wesley M MarinUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA 94158.
Ravi DandekarUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA 94158.
Peter ParhamDepartment of Structural Biology, Stanford University, Stanford, CA 94305.
Caroline M TannerUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA 94158.
Stephen L HauserUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA 94158.
Marcelo Fernandez-ViñaDepartment of Pathology, Stanford University, Palo Alto, CA 94304.
Jorge R OksenbergUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA 94158.
University of California, San Francisco · USPalo Alto University · USStanford University · USStanford Blood Center · USUniversity of Colorado Denver · US

Funding

KIR association studies in neurological diseasesU19NS095774 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERNANDEZ-VINA, MARCELO, OKSENBERG, JORGE R. · 2015 to 2019
$7.0M
BMI Bioinformatics Training GrantsT32GM067547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERNANDEZ, RYAN D. · 2003 to 2022
$6.6M
NINDS NIH HHS U19 NS095774
6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disease in which genetic risk has been mapped to

Indexed as

GenotypeModels, MolecularAmino Acid MotifsFemaleGenotyping TechniquesHLA-DRB1 ChainsHumansMaleParkinson DiseaseRisk FactorsSmokingHLA-DRB1 ChainsHLAParkinson’s diseaseshared epitopesmoking

Identifiers

PMID30910980
PMCPMC6462083
OpenAlexW2923945096

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.