Evidence map›Paper›PMID 30910957›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins.

Stacy A Malaker, Kayvon Pedram, Michael J Ferracane, Barbara A Bensing, Venkatesh Krishnan, Christian Pett, Jin Yu, Elliot C Woods, Jessica R Kramer, Ulrika Westerlind and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 278 citations in OpenAlex.

  1. Review
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  4. Deep Learning Prediction of O-Glycopeptide Tandem Mass Spectra Enhances O-Glycoproteomics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Stacy A MalakerDepartment of Chemistry, Stanford University, Stanford, CA 94305.ORCID 0000-0003-2382-5067
Kayvon PedramDepartment of Chemistry, Stanford University, Stanford, CA 94305.ORCID 0000-0001-8365-1826
Michael J FerracaneDepartment of Chemistry, University of Redlands, Redlands, CA 92373.
Barbara A BensingDepartment of Medicine, San Francisco Veterans Affairs Medical Center and University of California, San Francisco, CA 94143.
Venkatesh KrishnanStanford Women's Cancer Center, Division of Gynecologic Oncology, Stanford University, Stanford, CA 94305.
Christian PettLeibniz-Institut für Analytische Wissenschaften (ISAS), 44227 Dortmund, Germany.
Jin YuLeibniz-Institut für Analytische Wissenschaften (ISAS), 44227 Dortmund, Germany.
Elliot C WoodsDepartment of Chemistry, Stanford University, Stanford, CA 94305.
Jessica R KramerDepartment of Bioengineering, University of Utah, Salt Lake City, UT 84112.
Ulrika WesterlindLeibniz-Institut für Analytische Wissenschaften (ISAS), 44227 Dortmund, Germany.
Oliver DorigoStanford Women's Cancer Center, Division of Gynecologic Oncology, Stanford University, Stanford, CA 94305.
Carolyn R BertozziDepartment of Chemistry, Stanford University, Stanford, CA 94305; bertozzi@stanford.edu.ORCID 0000-0003-4482-2754
Stanford University · USLeibniz Institute for Analytical Sciences - ISAS · DEHoward Hughes Medical Institute · USSan Francisco VA Medical Center · USUniversity of Redlands · USUniversity of Utah · US

Funding

Investigations of Golgi EnzymesR01GM059907 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BERTOZZI, CAROLYN · 1999 to 2016
$5.9M
Targeting the Cancer GlycocalyxR01CA227942 · NCI · STANFORD UNIVERSITY · PI Carolyn Bertozzi · 2019 to 2026
$3.6M
HARNESSING THE ORAL MICROBIOME TO CREATE NOVEL GLYCAN-BINDING PROBESU01CA221244 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI RUHL, STEFAN HANS-KLAUS, SULLAM, PAUL M. · 2017 to 2019
$1.4M
NCI NIH HHS R01 CA227942NCI NIH HHS U01 CA221244NIGMS NIH HHS R01 GM059907
6 · The paper itself

Abstract

Mucin domains are densely

Indexed as

Amino Acid MotifsAntigens, CDAntigens, Differentiation, MyelomonocyticEscherichia coliEscherichia coli ProteinsHumansLectinsMass SpectrometryMetalloendopeptidasesMucinsNeoplasm ProteinsSialic Acid Binding Immunoglobulin-like LectinsSubstrate SpecificityAntigens, CDAntigens, Differentiation, MyelomonocyticEscherichia coli ProteinsLectinsMetalloendopeptidasesMucinsNeoplasm ProteinsSialic Acid Binding Immunoglobulin-like LectinsSIGLEC7 protein, humanSIGLEC9 protein, humanStcE protein, E coliglycoproteomicsmucinO-glycosylationproteaseSiglec

Identifiers

PMID30910957
PMCPMC6462054
OpenAlexW2924483954

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.