Evidence map›Paper›PMID 30910842›Full record

ArticleBioscience reports2019

LncRNA DANCR contributes to tumor progression via targetting miR-216a-5p in breast cancer: lncRNA DANCR contributes to tumor progression.

Weiyang Tao, Chunyang Wang, Bifa Zhu, Guoqiang Zhang, Da Pang

Abstract read
In one paragraph

Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  10. Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Metformin and long non-coding RNAs in breast cancer.Journal of translational medicine · 2023
    Review
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  16. Expression ofMolecular medicine reports · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Weiyang TaoDepartment of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin City, Heilongjiang Province, P.R. China cugbo28@163.com.ORCID 0000-0002-1468-308X
Chunyang WangDepartment of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin City, Heilongjiang Province, P.R. China.
Bifa ZhuDepartment of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin City, Heilongjiang Province, P.R. China.
Guoqiang ZhangDepartment of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin City, Heilongjiang Province, P.R. China.
Da PangDepartment of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin City, Heilongjiang Province, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer, the most frequently occurring malignant tumor, has high mortality rate, especially triple-negative breast cancer (TNBC). LncRNA-differentiation antagonizing non-protein coding RNA (lncRNA DANCR) has been found that its aberrant expression was associated with tumor progression and it was promising to be a potential target for cancer therapy. The goal of the present study was to explore the biological effects and underlying mechanism of DANCR in breast cancer. Our results showed that DANCR was up-regulated in TNBC tissues and breast cancer cells compared with normal breast tissues and cells, and higher DANCR level suggested poorer prognosis, implying that it was promising to be a novel biomarker used for TNBC diagnosis and prognosis. To better research the functions and mechanism of DANCR on breast cancer cells, we selected two cell lines used for next study: one TNBC cell line-MDA-MB-231 and one ER-positive breast cancer cell line-MCF-7. Further study indicated that DANCR overexpression significantly promoted cell proliferation and invasion

Indexed as

Gene Expression Regulation, NeoplasticCell Line, TumorCell MovementDisease ProgressionFemaleHumansMCF-7 CellsMicroRNAsNeoplasm InvasivenessRNA, Long NoncodingTriple Negative Breast NeoplasmsDANCR long noncoding RNA, humanMicroRNAsMIRN216 microRNA, humanRNA, Long NoncodingLncRNA DANCRmiRNA-216a-5ptriple negative breast cancertumor progression

Identifiers

PMID30910842
PMCPMC6481242

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.