Evidence map›Paper›PMID 30910831›Full record

ArticleJournal of cell science2019

New quantitative approach reveals heterogeneity in mitochondrial structure-function relations in tumor-initiating cells.

Brian Spurlock, Priyanka Gupta, Malay Kumar Basu, Avik Mukherjee, Anita B Hjelmeland, Victor Darley-Usmar, Danitra Parker, McKenzie E Foxall, Kasturi Mitra

Abstract read
In one paragraph

Article in Journal of cell science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Mito-SinCeMethods in molecular biology (Clifton, N.J.) · 2021
    Article
  12. Hyperpolarized mitochondria accumulate inJournal of cell science · 2020
    Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Brian SpurlockDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Priyanka GuptaDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Malay Kumar BasuDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Avik MukherjeeDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-6193-0314
Anita B HjelmelandDepartment of Cell Development and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Victor Darley-UsmarDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Danitra ParkerDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
McKenzie E FoxallDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Kasturi MitraDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA kasturi@uab.edu.ORCID 0000-0003-3718-7094

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Sex hormones and arthritis in a long lived animal modelP30AG050886 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jianhua Zhang · 2015 to 2026
$11.3M
ROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5M
UAB CANCER RESEARCH EXPERIENCES FOR STUDENTS(CARES)R25CA076023 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SMITH, PETER R., WATERBOR, JOHN W · 1999 to 2020
$5.6M
RT-SQuARED-M method to study the precise role of mitochondria in the oxidative damage caused by environmental toxinsR33ES025662 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MITRA, KASTURI · 2018 to 2019
$1.1M
NCI NIH HHS R25 CA076023NIAMS NIH HHS P30 AR048311NIA NIH HHS P30 AG050886NIDDK NIH HHS P30 DK079626NIEHS NIH HHS R33 ES025662
6 · The paper itself

Abstract

Steady-state mitochondrial structure or morphology is primarily maintained by a balance of opposing fission and fusion events between individual mitochondria, which is collectively referred to as mitochondrial dynamics. The details of the bidirectional relationship between the status of mitochondrial dynamics (structure) and energetics (function) require methods to integrate these mitochondrial aspects. To study the quantitative relationship between the status of mitochondrial dynamics (fission, fusion, matrix continuity and diameter) and energetics (ATP and redox), we have developed an analytical approach called mito-SinCe

Indexed as

Adenosine TriphosphateAnimalsCell LineEnergy MetabolismFemaleHumansMicroscopy, ConfocalMitochondriaMitochondrial DynamicsMitochondrial ProteinsNeoplastic Stem CellsOvarian NeoplasmsOxidation-ReductionAdenosine TriphosphateMitochondrial ProteinsMethodMicroscopyMitochondrial ATPMitochondrial fission and fusionMitochondrial redoxOvarian tumor-initiating cellsSingle cells

Identifiers

PMID30910831
PMCPMC6526706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.