Evidence map›Paper›PMID 30910725›Full record

ArticleNeuroImage2019

Comparative modeling of transcranial magnetic and electric stimulation in mouse, monkey, and human.

Ivan Alekseichuk, Kathleen Mantell, Sina Shirinpour, Alexander Opitz

Registry-linked trialOpen access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05657392 (Examination of Changes in Quantitative EEG Parameters Based on Repetitive Transcranial Magnetic Stimulation), which is not on this map. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05657392 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Examination of Changes in Quantitative EEG Parameters Based on Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment in Patients With Post Stroke

TypeinterventionalSponsorIzmir Katip Celebi UniversityRan2021 to 2024Enrolled50ConditionsStroke, Stroke, Ischemic, Stroke/Brain AttackArmsrepetitive Transcranial Magnetic Stimulation (rTMS), 32 electrode electroencephalography (EEG)
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.

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  17. [Quantitative analysis of transcranial temporal interference stimulation in rodents: A simulation study on electrode configurations].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ivan AlekseichukDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA. Electronic address: ialeksei@umn.edu.
Kathleen MantellDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Sina ShirinpourDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Alexander OpitzDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA. Electronic address: aopitz@umn.edu.
University of Minnesota · US

Funding

CRCNS: Collaboration toward an experimentally validated multiscale model of rTMSR01MH118930 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI QUEISSER, GILLIAN · 2018 to 2020
$497k
NIMH NIH HHS R01 MH118930
6 · The paper itself

Abstract

Transcranial magnetic stimulation (TMS) and transcranial electric stimulation (TES) are increasingly popular methods to noninvasively affect brain activity. However, their mechanism of action and dose-response characteristics remain under active investigation. Translational studies in animals play a pivotal role in these efforts due to a larger neuroscientific toolset enabled by invasive recordings. In order to translate knowledge gained in animal studies to humans, it is crucial to generate comparable stimulation conditions with respect to the induced electric field in the brain. Here, we conduct a finite element method (FEM) modeling study of TMS and TES electric fields in a mouse, capuchin and macaque monkeys, and a human model. We systematically evaluate the induced electric fields and analyze their relationship to head and brain anatomy. We find that with increasing head size, TMS-induced electric field strength first increases and then decreases according to a two-term exponential function. TES-induced electric field strength strongly decreases from smaller to larger specimen with up to 100x fold differences across species. Our results can serve as a basis to compare and match stimulation parameters across studies in animals and humans.

Indexed as

Models, AnimalAnimalsBrainCebusFinite Element AnalysisHumansMacacaMiceTranscranial Direct Current StimulationTranscranial Magnetic StimulationTranslational Research, BiomedicalAnimal modelFinite element modelingNeuromodulationTranscranial electric stimulationTranscranial magnetic stimulation

Identifiers

PMID30910725
PMCPMC6536349
OpenAlexW2951191882

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.