Evidence map›Paper›PMID 30910724›Full record

ArticleNeuroImage2019

3D whole brain segmentation using spatially localized atlas network tiles.

Yuankai Huo, Zhoubing Xu, Yunxi Xiong, Katherine Aboud, Prasanna Parvathaneni, Shunxing Bao, Camilo Bermudez, Susan M Resnick, Laurie E Cutting, Bennett A Landman

Abstract read
In one paragraph

Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

167 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  5. Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Hippocampal Total, Subregion, and Subfield Volume Alterations in Late-Life Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
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  15. ECLARE: efficient cross-planar learning for anisotropic resolution enhancement.Journal of medical imaging (Bellingham, Wash.) · 2026
    Article
  16. Article
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  18. Characterizing Continuous and Discrete Hybrid Latent Spaces for Structural Connectomes.Proceedings of SPIE--the International Society for Optical Engineering · 2026
    Article
  19. CNN-based detection of pediatric lymphoma on whole body [American journal of nuclear medicine and molecular imaging · 2026
    Article
  20. Article

107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuankai HuoDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA. Electronic address: yuankai.huo@vanderbilt.edu.
Zhoubing XuDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA.
Yunxi XiongDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA.
Katherine AboudDepartment of Special Education, Vanderbilt University, Nashville, TN, USA.
Prasanna ParvathaneniDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA.
Shunxing BaoDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA.
Camilo BermudezDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
Susan M ResnickLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.
Laurie E CuttingDepartment of Special Education, Vanderbilt University, Nashville, TN, USA; Department of Psychology, Vanderbilt University, Nashville, TN, USA; Department of Pediatrics, Vanderbilt University, Nashville, TN, USA; Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA.
Bennett A LandmanDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA; Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA; Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.

Funding

Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Suzanne Elizabeth Schindler · 1985 to 2026
$69.5M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
Neuroimaging Predictors of Cognitive Decline, Impairment, and ResilienceZIAAG000191 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2025
$26.4M
Cognitive and Neural Processes in Reading ComprehensionR01HD044073 · NICHD · VANDERBILT UNIVERSITY · PI CUTTING, LAURIE E · 2004 to 2019
$8.1M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Controlling Quality and Capturing Uncertainty in Advanced Diffusion Weighted MRIR01EB017230 · NIBIB · VANDERBILT UNIVERSITY · PI LANDMAN, BENNETT A. · 2015 to 2024
$5.1M
Predicting Late-Emerging RD: Neurobiological and Cognitive FactorsR01HD067254 · NICHD · VANDERBILT UNIVERSITY · PI CUTTING, LAURIE E · 2010 to 2014
$2.9M
Computer-Assited Functional NeurosurgeryR01NS095291 · NINDS · VANDERBILT UNIVERSITY · PI DAWANT, BENOIT M., DHAESE, PIERRE F. · 2015 to 2018
$2.4M
Training Program for Innovative Engineering Research in Surgery and InterventionT32EB021937 · NIBIB · VANDERBILT UNIVERSITY · PI Dario J Englot, Michael Ian Miga · 2016 to 2026
$2.3M
NCATS NIH HHS UL1 TR000445NCRR NIH HHS S10 RR031634NCRR NIH HHS UL1 RR024975NEI NIH HHS R21 EY024036NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066507NIBIB NIH HHS R01 EB017230NIBIB NIH HHS R03 EB012461NIBIB NIH HHS T32 EB021937NICHD NIH HHS N01 HD023343NICHD NIH HHS R01 HD044073NICHD NIH HHS R01 HD067254NICHD NIH HHS U54 HD083211NIH HHS S10 OD020154NINDS NIH HHS R01 NS095291
6 · The paper itself

Abstract

Detailed whole brain segmentation is an essential quantitative technique in medical image analysis, which provides a non-invasive way of measuring brain regions from a clinical acquired structural magnetic resonance imaging (MRI). Recently, deep convolution neural network (CNN) has been applied to whole brain segmentation. However, restricted by current GPU memory, 2D based methods, downsampling based 3D CNN methods, and patch-based high-resolution 3D CNN methods have been the de facto standard solutions. 3D patch-based high resolution methods typically yield superior performance among CNN approaches on detailed whole brain segmentation (>100 labels), however, whose performance are still commonly inferior compared with state-of-the-art multi-atlas segmentation methods (MAS) due to the following challenges: (1) a single network is typically used to learn both spatial and contextual information for the patches, (2) limited manually traced whole brain volumes are available (typically less than 50) for training a network. In this work, we propose the spatially localized atlas network tiles (SLANT) method to distribute multiple independent 3D fully convolutional networks (FCN) for high-resolution whole brain segmentation. To address the first challenge, multiple spatially distributed networks were used in the SLANT method, in which each network learned contextual information for a fixed spatial location. To address the second challenge, auxiliary labels on 5111 initially unlabeled scans were created by multi-atlas segmentation for training. Since the method integrated multiple traditional medical image processing methods with deep learning, we developed a containerized pipeline to deploy the end-to-end solution. From the results, the proposed method achieved superior performance compared with multi-atlas segmentation methods, while reducing the computational time from >30 h to 15 min. The method has been made available in open source (https://github.com/MASILab/SLANTbrainSeg).

Indexed as

Deep LearningAtlases as TopicBrainHumansImage Processing, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingNeuroimagingBrain segmentationDeep learningLabel fusionMulti-atlasNetwork tiles

Identifiers

PMID30910724
PMCPMC6536356

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.